A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver disease

作者全名："Ullah, Amin; Ud Din, Ahmad; Ding, Wen; Shi, Zheng; Pervaz, Sadaf; Shen, Bairong"

作者地址："[Ullah, Amin; Ud Din, Ahmad; Ding, Wen; Shen, Bairong] Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Xinchuan Rd 2222, Chengdu, Sichuan, Peoples R China; [Shi, Zheng] Chengdu Univ, Clin Med Coll, Clin Genet Lab, Chengdu 610106, Peoples R China; [Shi, Zheng] Chengdu Univ, Affiliated Hosp, Chengdu 610106, Peoples R China; [Pervaz, Sadaf] Chongqing Med Univ, Sch Publ Hlth, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China"

通信作者："Ullah, A; Shen, BR (通讯作者)，Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Xinchuan Rd 2222, Chengdu, Sichuan, Peoples R China."

来源：REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000960761100001

JCR分区：Q1

影响因子：8.2

年份：2023

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文献类型：Review; Early Access

关键词：Obesity; CXC chemokines; Type 2 diabetes; Nonalcoholic fatty liver disease; Therapeutic potential; Inflammation

摘要："Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory cytokines as a consequence of the low-grade systemic inflammation that characterizes obesity. This low-grade systemic inflammation can lead to insulin resistance (IR) and metabolic complications, such as type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). Although the CXC chemokines consists of numerous regulators of inflammation, cellular function, and cellular migration, it is still unknown that how CXC chemokines and chemokine receptors contribute to the development of metabolic diseases (such as T2D and NAFLD) during obesity. In light of recent research, the objective of this review is to provide an update on the linkage between the CXC chemokine, obesity, and obesity-related metabolic diseases (T2D and NAFLD). We explore the differential migratory and immunomodulatory potential of CXC chemokines and their mechanisms of action to better understand their role in clinical and laboratory contexts. Besides that, because CXC chemokine profiling is strongly linked to leukocyte recruitment, macrophage recruitment, and immunomodulatory potential, we hypothesize that it could be used to predict the therapeutic potential for obesity and obesity-related diseases (T2D and NAFLD)."

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