SCAT8/miR-125b-5p axis triggers malignant progression of nasopharyngeal carcinoma through SCARB1

作者全名："Jiang, Chunmao; Feng, Dandan; Zhang, Yu; Yang, Kun; Hu, Xiaotong; Xie, Qian"

作者地址："[Jiang, Chunmao; Hu, Xiaotong; Xie, Qian] Army Med Univ, Daping Hosp, Dept Hlth Management, Chongqing 400010, Peoples R China; [Feng, Dandan] Army Med Univ, Daping Hosp, Dept Otolaryngol Head & Neck Surg, Chongqing 400010, Peoples R China; [Zhang, Yu] Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Chongqing 400010, Peoples R China; [Yang, Kun] Chongqing Med Univ, Affiliated Hosp 2, Dept Hlth Management Ctr, Chongqing 400010, Peoples R China"

通信作者："Xie, Q (通讯作者)，Army Med Univ, Daping Hosp, Dept Hlth Management, Chongqing 400010, Peoples R China."

来源：BMC MOLECULAR AND CELL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000961814300001

JCR分区：Q4

影响因子：2.8

年份：2023

卷号：24

期号：1

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结束页：　

文献类型：Article

关键词：Nasopharyngeal carcinoma; ceRNA; SCARB1; Cell proliferation; Cell migration

摘要："Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasopharyngeal carcinoma, which regulate the progression of nasopharyngeal carcinoma through the ceRNA network. SCARB1 plays an essential role in nasopharyngeal carcinoma. However, the mechanism underlying the regulation of SCARB1 in nasopharyngeal carcinoma through non-coding RNAs remains unclear. Our findings indicated that the SCAT8/miR-125b-5p axis promoted the malignant progression of nasopharyngeal carcinoma by driving the expression of SCARB1. Mechanistically, the expression of SCARB1 could be regulated by the lncRNA, SCAT8 and the microRNA, miR-125b-5p. Moreover, as a ceRNA of miR-125b-5p, SCAT8 can not only regulate the expression of SCARB1, but also regulate the malignant progression of nasopharyngeal carcinoma. Notably, our results reveal a novel ceRNA regulatory network in nasopharyngeal carcinoma, which could serve as a potential target for the diagnosis and treatment of nasopharyngeal carcinoma."

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