Therapeutic dose and long-term efficacy of high-intensity focused ultrasound ablation for different types of uterine fibroids based on signal intensity on T2-weighted MR images

作者全名："Wang, Yangyang; Gong, Chunmei; He, Min; Lin, Zhenjiang; Xu, Feng; Peng, Song; Zhang, Lian"

作者地址："[Wang, Yangyang; Gong, Chunmei; He, Min; Lin, Zhenjiang; Xu, Feng; Zhang, Lian] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Gong, Chunmei; Zhang, Lian] Chongqing Haifu Hosp, Chongqing, Peoples R China; [Lin, Zhenjiang] Zunyi Med Univ, Dept Gynecol, Affiliated Hosp, Zunyi, Peoples R China; [Xu, Feng] Shijiazhuang Peoples Hosp, Dept Gynecol, Shijiazhuang, Peoples R China; [Peng, Song] Chongqing Med Univ, Dept Radiol, Women & Childrens Hosp, Chongqing, Peoples R China; [Zhang, Lian] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med & Engn, Chongqing 400016, Peoples R China"

通信作者："Zhang, L (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med & Engn, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000962012800001

JCR分区：Q2

影响因子：3.1

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound ablation; uterine fibroids; T2-weighted image; therapeutic dose; long-term efficacy; re-intervention rate

摘要："Objective To investigate the therapeutic dose and long-term efficacy of high-intensity focused ultrasound (HIFU) ablation for different types of uterine fibroids based on signal intensity on T2-weighted MR images (T2WI). Materials and methods Four hundred and one patients with a solitary uterine fibroid treated with HIFU were classified into four groups consisting of extremely hypointense, hypointense, isointense and hyperintense fibroids. Each group was further classified into two subtypes: homogeneous and heterogeneous, based on signal homogeneity of fibroids. The therapeutic dose and long-term follow-up results were compared. Results There were significant differences in treatment time, sonication time, treatment intensity, total treatment dosage, treatment efficiency, energy-efficiency factor (EEF) and non-perfused volume (NPV) ratio among the four groups (p<.05). The average NPV ratio achieved in patients with extremely hypointense, hypointense, isointense and hyperintense fibroids was 75.2 +/- 14.6%, 71.1 +/- 15.6%, 68.2 +/- 17.3% and 67.8 +/- 16.6%, respectively; the re-intervention rates at 36 months after HIFU were 8.4%, 10.3%, 12.5% and 6.1%, respectively. Sonication time, treatment intensity and total energy for heterogeneous fibroids were greater than that for homogeneous fibroids in patients with extremely hypointense fibroids (p<.05). The treatment time for heterogeneous fibroids was significantly longer than that for homogeneous fibroids in patients with isointense fibroids (p<.05). Multivariate ordered logistic regression analysis showed that the ablation volume of fibroids and treatment time were related to NPV ratio (p<.05). Conclusion Every group of patients obtained satisfactory long-term results. Hyperintense fibroids are difficult to treat by HIFU. Heterogeneous fibroids are more difficult to treat with HIFU than homogeneity fibroids."

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