Laser-activated nanoparticles for ultrasound/photoacoustic imaging-guided prostate cancer treatment

作者全名："Xiao, Linkang; Wu, Yunfang; Dai, Junyong; Zhang, Weili; Cao, Yang"

作者地址："[Xiao, Linkang; Wu, Yunfang; Dai, Junyong; Zhang, Weili; Cao, Yang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Urol Surg,Chongqing Key Lab Ultrasound Mol Im, Chongqing, Peoples R China; [Xiao, Linkang] Chongqing Gen Hosp, Chongqing, Peoples R China; [Wu, Yunfang] Chongqing Wanzhou Dist Maternal & Child Hlth Hosp, Chongqing, Peoples R China; [Dai, Junyong] Chongqing Univ Canc Hosp, Chongqing, Peoples R China"

通信作者："Zhang, WL; Cao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Urol Surg,Chongqing Key Lab Ultrasound Mol Im, Chongqing, Peoples R China."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000964237800001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：laser-activated nanoparticles; photothermal therapy (PPT); photoacoustic imaging (PAI); ultrasound; prostate cancer

摘要："Prostate cancer (PCa) is the most common malignant tumor in men. Prostate-specific membrane antigen (PSMA), which is overexpressed on the surface of Prostate cancer cells, may serve as a potential therapeutic target. Recently, image-guided and targeted therapy for prostate cancers has attracted much attention by using Prostate-specific membrane antigen targeting nanoparticle. In this study, we produced PSMA-targeted light-responsive nanosystems. These nanosystems of liquid perfluorocarbon cores and polymer shells were loaded with the photosensitizer IR780 and therapeutic drugs paclitaxel. The liquid perfluorocarbon (PFP) in nanoparticles can perform ultrasound-enhanced imaging by liquid-gas transition and promote the deliver and release of paclitaxel. IR780 can perform photothermal therapy (PTT) guided by photoacoustic (PA) imaging. Combination treatment with photothermal therapy and chemotherapy exhibited excellent inhibition of cell proliferation in vitro and a significant therapeutic effect in vivo. In conclusion, we successfully formulated PSMA-targeted nanosystems with precision targeting and ultrasound/PA dual-modality imaging for anti-tumor effects."

基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0120]; Senior Medical Talents Program of Chongqing for Young and Middle-aged

基金资助正文："This work was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0120), Senior Medical Talents Program of Chongqing for Young and Middle-aged."