Real-time monitoring of NIR-triggered drug release from phase-changeable nanodroplets by photoacoustic/ultrasound imaging

作者全名："Cao, Yang; Dumani, Diego S.; Hallam, Kristina A.; Emelianov, Stanislav Y.; Ran, Haitao"

作者地址："[Cao, Yang; Ran, Haitao] Engn Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Med, Chongqing Key Lab Ultrasound Mol Imaging,Inst Ultr, Chongqing 400010, Peoples R China; [Dumani, Diego S.; Hallam, Kristina A.; Emelianov, Stanislav Y.] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA; [Dumani, Diego S.; Hallam, Kristina A.; Emelianov, Stanislav Y.] Emory Univ, Sch Med, Atlanta, GA 30332 USA; [Dumani, Diego S.; Hallam, Kristina A.; Emelianov, Stanislav Y.] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA; [Dumani, Diego S.] Univ Costa Rica, Sch Elect Engn, San Jose 115012060, Costa Rica"

通信作者："Cao, Y (通讯作者)，Engn Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Med, Chongqing Key Lab Ultrasound Mol Imaging,Inst Ultr, Chongqing 400010, Peoples R China."

来源：PHOTOACOUSTICS

ESI学科分类：ENGINEERING

WOS号：WOS:000966743300001

JCR分区：Q1

影响因子：7.9

年份：2023

卷号：30

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Photoacoustic; ultrasound imaging; Perfluorocarbon nanodroplets; Optical droplet vaporization; Controlled drug release

摘要："Optical-responsive nanodroplets have recently been studied as a new mode of remotely controlled drug delivery. As a class of new emerging smart drug carriers, NIR-absorber-loaded perfluorocarbon nanodroplets can be converted into gas bubbles through laser stimulation, called optical droplet vaporization (ODV), which provides a potential strategy to deliver therapeutic agents to solid tumors on demand. However, there is a lack of suitable technologies to monitor these drug-loaded nanodroplet behaviors in vivo, and control the site and amount of drug released. In this study, ultrasound and photoacoustic imaging technology were applied to directly monitor optical-responsive, drug-loaded nanodroplets within the tissue. We explored the effects of laser energy, repetition rate, and number of pulses on the release profiles of the delivered drug as well as ultrasound and photoacoustic imaging signal-intensity curves. The conducted studies demonstrated that this noninvasive technology helped determine the optimum time point for laser activation on accumulated drug-loaded nanodroplets within tissues, allowing for the potential to effectively treat pathologies while minimizing drug-related toxicities."

基金机构："Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0120]; Senior Medical Talents Pro- gram of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University"

基金资助正文："Funding This work was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0120) , Senior Medical Talents Pro- gram of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."