Br?nsted-Acid-Catalyzed Friedel-Crafts Reaction and Electrocyclization Cascade of Indoles with ?-Functionalized Carbonyls

作者全名："Tan, Linbo; Xu, Teling; Zhang, Xueyan; Luo, Juan; Xiao, Xiaoqin; Li, Lian; Huang, Shanshan; Tang, Qiang"

作者地址："[Tan, Linbo] Chongqing Med Univ, Childrens Hosp, Coll Pharm, Chongqing 400016, Peoples R China; [Xu, Teling; Zhang, Xueyan; Li, Lian; Huang, Shanshan] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Luo, Juan] Chongqing Med Univ, Ctr Lab Teaching & Management, Chongqing 400016, Peoples R China; [Xiao, Xiaoqin] Dazhou Cent Hosp, Dazhou 635000, Sichuan, Peoples R China; [Tang, Qiang] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Tang, Q (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：ORGANIC LETTERS

ESI学科分类：CHEMISTRY

WOS号：WOS:000967544800001

JCR分区：Q1

影响因子：5.2

年份：2023

卷号：25

期号：15

开始页：2600

结束页：2605

文献类型：Article

关键词：　

摘要："Reported here is an efficient Friedel-Crafts-type reaction followed by electrocyclization cascade under an air atmosphere, employing readily available building blocks as starting materials, ethanol as a solvent, and Bronsted acid as a catalyst. On the basis of the cascade strategy, 2-(2aminophenyl)-9H-carbazole has been furnished with excellent regioselectivity, exceptional functional group tolerance, and tolerated large-scale synthesis. Furthermore, one-pot syntheses of quino[3,4-a]carbazoles have been accomplished, demonstrating the broad synthetic utility of this strategy in the synthesis of valuable heteroaryl-annulated [a]carbazoles."

基金机构：Natural Science Foundation of Chongqing City of China [CSTB2022NSCQ-MSX0847]

基金资助正文：The author s appreciate the financial support from the Natural Science Foundation of Chongqing City of China (CSTB2022NSCQ-MSX0847) .