Association Between Platelet Indices and Preoperative Deep Vein Thrombosis in Elderly Patients Undergoing Total Joint Arthroplasty: A Retrospective Study

作者全名："Xiong, Xiaojuan; Li, Ting; Yu, Shuang; Cheng, Bo"

作者地址："[Xiong, Xiaojuan; Li, Ting; Yu, Shuang] Army Med Univ, Daping Hosp, Army Med Ctr PLA, Dept Anesthesiol, Chongqing, Peoples R China; [Cheng, Bo] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China; [Cheng, Bo] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 1 Youyi Rd, Chongqing 400000, Peoples R China"

通信作者："Cheng, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, 1 Youyi Rd, Chongqing 400000, Peoples R China."

来源：CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000967610300001

JCR分区：Q3

影响因子：2.9

年份：2023

卷号：29

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：total joint arthroplasty; mean platelet volume; platelet distribution width; platelet large cell ratio; plateletcrit; deep vein thrombosis

摘要："To investigate the association between platelet (PLT) indices and preoperative deep vein thrombosis (DVT) in elderly patients undergoing total joint arthroplasty (TJA). A total of 1391 patients were enrolled. We created receiver operator characteristic (ROC) curve using the ratio of PLT indices to DVT before TJA, divided the enrolled patients into groups based on the cut-off value, and then analyzed risk factors for DVT before TJA in the multivariate binary logistic regression analysis. Preoperative DVT occurred in 103 cases. Based on the ROC curve, we determined that the cut-off values for PLT, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) were 202 x 10(9)/L, 11.4 fL, 13.2 fL, 34.6%, and 0.228%. And the areas under the curve were 0.606, 0.605, 0.617, 0.616, and 0.598. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with PLT >= 202 x 10(9)/L, MPV <= 11.4 fL, PDW <= 13.2 fL, P-LCR <= 34.6%, and PCT >= 0.228% increased by 2.32 (P < .001, 95% confidence interval [CI] [1.50-3.60]), 1.86 (P < .001, 95% CI [1.22-2.83]), 2.17 (P < .001, 95% CI [1.43-3.31]), 2.27 (P < .001, 95% CI [1.50-3.45]), and 1.76 times (P = .013, 95% CI [1.13-2.76]), respectively. Age, P < .001, odds ratio (OR) = 1.08, 95% CI [1.04-1.11]; corticosteroid use, P = .011, OR = 3.66, 95% CI [1.34-9.96]. We found that increased PLT count and PCT, decreased MPV, PDW, and P-LCR, old age, and corticosteroid use were independent risk factors for preoperative DVT in elderly TJA patients."

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