"Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-? and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms"

作者全名："Tan, Yongjun; Zhou, Li; Huang, Jiagui; Chen, Xia; Wu, Youlin; Song, Xiaosong; Wang, Jiani; Hu, Hua; Yang, Qin"

作者地址："[Tan, Yongjun; Zhou, Li; Huang, Jiagui; Chen, Xia; Wu, Youlin; Song, Xiaosong; Wang, Jiani; Yang, Qin] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Hu, Hua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Yang, Qin] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Hu, Hua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Yang, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Hu, H (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：NEUROPSYCHIATRIC DISEASE AND TREATMENT

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000967811400001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：19

期号：　

开始页：785

结束页：800

文献类型：Article

关键词：vitamin B12; adolescents; inflammatory mediators; depression; anxiety

摘要："Purpose: To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine (tHcy), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) levels, to analyze the relationship between these parameters and the severity of anxiety or depressive symptoms, and to explore the possible factors associated with abnormal levels of these parameters in adolescents with anxiety or depressive symptoms. Methods: Adolescent (aged 12-18 years) outpatients with anxiety or depressive symptoms were recruited. The patient health questionnaire-9 and generalized anxiety disorder scale-7 were used to measure the severity of depression and anxiety. Serum vitamin B12, folate, tHcy, IL-6, TNF-alpha, and CRP levels were determined. Results: 128 subjects were recruited. The prevalence of vitamin B12 and folate deficiency, tHcy, TNF-alpha, IL-6, and CRP elevation was 8.6%, 10.2%, 25.8%, 14.8%, 21.9%, and 10.2%, respectively, in adolescents with anxiety or depressive symptoms. Lower vitamin B12 levels were correlated with a higher risk of severe anxiety and depressive symptoms. The severity of some symptoms of anxiety or depression were weakly correlated with vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were not associated with inflammatory mediators. Vitamin B12 deficiency was associated with older age and higher tHcy levels. Folate deficiency was associated with elevated tHcy. Elevated tHcy was associated with lower vitamin B12 and folate levels. IL-6 elevation was associated with elevated CRP and TNF-alpha. CRP elevation was associated with older age, higher BMI, and current drinking. Conclusion: Lower vitamin B12 levels were correlated with a higher risk of severe anxiety or depressive symptoms. Weak correlations were observed between the severity of some symptoms of anxiety or depression and vitamin B12, folate, tHcy, IL-6, and CRP levels. Vitamin B12, folate, and tHcy levels were related to each other. IL-6 elevation was associated with elevated CRP and TNF-alpha. CRP elevation was associated with older age, higher BMI, and current drinking."

基金机构："National Natural Science Foundation of China [82171456, 81971229]; Natural Science Foundation of Chongqing Science and Technology Commission [cstc 2021jcyj-msxmX0263]"

基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (Grant no. 82171456 and 81971229) and the Natural Science Foundation of Chongqing Science and Technology Commission (Grant no. cstc 2021jcyj-msxmX0263) .