"Analysis of clinical characteristics and automatic monitoring of drug-induced arrhythmias in 167,546 inpatients"

作者全名："Guo, Haili; Li, Peng; Guo, Daihong; Gao, Ao; Zhao, Pengzhi; Fu, An; Li, Chao; Lu, Jingchuang"

作者地址："[Guo, Haili; Li, Peng; Guo, Daihong; Gao, Ao; Zhao, Pengzhi; Fu, An; Li, Chao; Lu, Jingchuang] Chinese Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Dept Pharm, Beijing 100853, Peoples R China; [Lu, Jingchuang] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Guo, DH (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Dept Pharm, Beijing 100853, Peoples R China."

来源：EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000967859500001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Drug-induced arrhythmias; Automatic monitoring; Adverse drug reaction; Incidence; Pharmacovigilance

摘要："ObjectiveThe purpose of this study was to analyze the occurrence characteristics, clinical manifestations, medication distribution, and incidence of drug-induced arrhythmias in a real-world inpatient population.MethodsAccording to the inclusion and exclusion criteria as well as the ADR evaluation criteria, we retrospectively evaluated hospitalized patients in 2019 using the arrhythmia module of the Adverse Drug Event Active Surveillance and Assessment System-II (ADE-ASAS-II). A detailed analysis was performed on the demographic data, ADR manifestations, and medication distribution of 2097 patients with drug-induced arrhythmias and QT interval prolongation.ResultsOf the 167,546 hospitalized patients, there were 1809 cases of drug-induced arrhythmias, with an incidence of 1.08%. The ADRs in 45.35% of positive patients occurred within 3 days after medication administration, and 46.73% of the patients were 65 years old or older. The predominant ADRs identified in this study were extrasystole, tachycardia, and QT interval prolongation, of which the incidence was 0.20%. Levofloxacin was the most involved drug, and levofloxacin-associated rates of incidence of arrhythmia and QT interval prolongation were 1.24% and 0.44%, respectively. The risk factors for drug-induced arrhythmias were male sex, advanced age, emaciation, obesity, and underlying illnesses such as cardiovascular diseases, diabetes mellitus, cerebrovascular diseases, and hepatic and renal inadequacy (P < 0.05).ConclusionThe incidence of drug-induced arrhythmias was in the range of common, while QTc interval prolongation was occasional. It is necessary to pay attention to patients with risk factors."

基金机构：Key Project of Military Medical Innovation Project in 2017 [17CXZ010]; "the Project of Monitoring and Evaluation of the Use of Key Clinical Drugs" by the Chinese Association of Research Hospitals [Y2021FH-YWPJ01]

基金资助正文：This study was supported by the Key Project of Military Medical Innovation Project in 2017 (No. 17CXZ010) and "the Project of Monitoring and Evaluation of the Use of Key Clinical Drugs" commissioned by the Chinese Association of Research Hospitals (No. Y2021FH-YWPJ01).