Effects of Growth Hormone on Adult Human Gonads: Action on Reproduction and Sexual Function

作者全名："Zhou, Xin-Yi; Ma, Jia-Ni; Shen, Ya-Yin; Xie, Xue-Rui; Ren, Wei"

作者地址："[Zhou, Xin-Yi; Ma, Jia-Ni; Shen, Ya-Yin; Xie, Xue-Rui; Ren, Wei] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Ren, W (通讯作者)，Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000969245800001

JCR分区：Q3

影响因子：2.8

年份：2023

卷号：2023

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Growth hormone (GH), which is commonly considered to be a promoter of growth and development, has direct and indirect effects on adult gonads that influence reproduction and sexual function of humans and nonhumans. GH receptors are expressed in adult gonads in some species including humans. For males, GH can improve the sensitivity of gonadotropins, contribute to testicular steroidogenesis, influence spermatogenesis possibly, and regulate erectile function. For females, GH can modulate ovarian steroidogenesis and ovarian angiogenesis, promote the development of ovarian cells, enhance the metabolism and proliferation of endometrial cells, and ameliorate female sexual function. Insulin-like growth factor-1 (IGF-1) is the main mediator of GH. In vivo, a number of the physiological effects of GH are mediated by GH-induced hepatic IGF-1 and local IGF-1. In this review, we highlight the roles of GH and IGF-1 in adult human gonads, clarify potential mechanisms, and explore the efficacy and the risk of GH supplementation in associated deficiency and assisted reproductive technologies. Besides, the effects of excess GH on adult human gonads are discussed as well."

基金机构："Changchun Genescience Pharmaceutical Co., Ltd [cqmuhx2022001]; Special Funded Project for Scientific and Technological Innovation in Social Undertakings and Livelihood Security of the Chongqing Science and Technology Committee [cstc2015shmszx1067]"

基金资助正文："AcknowledgmentsThis work was supported by Changchun Genescience Pharmaceutical Co., Ltd (grant no. cqmuhx2022001) and the Special Funded Project for Scientific and Technological Innovation in Social Undertakings and Livelihood Security of the Chongqing Science and Technology Committee (grant no. cstc2015shmszx1067)."