AIE biofluorescent probe based on twisted cucurbit[14]uril for the detection of Fe(CN)(6)(3-) anion in solutions and live kidney cells

作者全名："Zhang, Wei; Yang, Li; Luo, Yang; Xiao, Han; Yang, Haiping; Ni, Xinlong; Tao, Zhu; Xiao, Xin"

作者地址："[Zhang, Wei; Luo, Yang; Ni, Xinlong; Tao, Zhu; Xiao, Xin] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Inst Appl Chem, Guiyang 550025, Peoples R China; [Yang, Li; Xiao, Han; Yang, Haiping] Chongqing Med Univ, Dept Nephrol, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China; [Xiao, Xin] Guizhou Univ, Dept Chem, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China"

通信作者："Yang, HP (通讯作者)，Chongqing Med Univ, Dept Nephrol, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China.; Xiao, X (通讯作者)，Guizhou Univ, Dept Chem, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China."

来源：SENSORS AND ACTUATORS B-CHEMICAL

ESI学科分类：CHEMISTRY

WOS号：WOS:000970605000001

JCR分区：Q1

影响因子：8.4

年份：2023

卷号：379

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Cucurbit[ n ]urils; Acute kidney injury; Sensitive Detection; Potential cyanide; Self -assembly

摘要："The kidney is one of the important organs for removing metabolites to maintain the stability of the internal environment. In this study, an AIE effect supramolecular fluorescent probe (TPAPy@tQ[14]) was constructed based on twisted cucurbit[14]uril (tQ[14]) and a triphenylamine derivative (TPAPy) through host-guest inter-action. TQ[14] could effectively inhibit the rotation of the TPAPy molecule, which triggered the AIE effect. This effect was manifested as the emission of bright yellow fluorescence. TPAPy@tQ[14] could ultrasensitively detect potential cyanide (K-3[Fe{CN}(6)]) in an aqueous solution at a detection limit as low as 3.28 x 10(-7) M. The unique nature of the positive charge of TPAPy@tQ[14] could rapidly cross the glomerular filtration barrier into HK-2 cells. In addition, this probe was successfully applied to distinguish excess Fe(CN)(6)(3-) in HK-2 cells for cell im-aging, providing a new detection method for early clinical identification of acute kidney injury (AKI)."

基金机构："National Natural Science Foundation of China [21861011, 21871064]; Technology Fund of Guizhou Province [2018-5781]; Science and Technology Research Project of Chongqing Education Commission [M201900401]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0098]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 21861011, 21871064) and the Technology Fund of Guizhou Province (No. 2018-5781) . Science and Technology Research Project of Chongqing Education Commission (Grant no. KJZD- M201900401) , Program for Youth Innovation in Future Medicine, Chongqing Medical University (no. W0098) ."