Plant-based diets and the risk of pancreatic cancer: a large prospective multicenter study

作者全名："Zhong, Guo-Chao; Li, Zhi; You, Ai-Jing; Zhu, Qian; Wang, Chun-Rui; Yang, Peng-Fei"

作者地址："[Zhong, Guo-Chao] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Li, Zhi] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [You, Ai-Jing] Chongqing Med Univ, Coll Clin Med 2, Student Off 2, Chongqing, Peoples R China; [Zhu, Qian] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Wang, Chun-Rui] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 2, Chongqing, Peoples R China; [Yang, Peng-Fei] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Zhong, GC (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：AMERICAN JOURNAL OF CLINICAL NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000971221100001

JCR分区：Q1

影响因子：7.1

年份：2023

卷号：117

期号：2

开始页：235

结束页：242

文献类型：Article

关键词：nutritional epidemiology; pancreatic cancer; plant-based diets; risk factor

摘要："Background: Plant-based diets have been recommended for improving health outcomes, including cancer. However, previous studies on plant-based diets and the risk of pancreatic cancer are scarce and fail to consider plant food quality. Objectives: We sought to examine the potential associations of 3 plant-based diet indices (PDIs) with the risk of pancreatic cancer in a US population. Methods: A population-based cohort of 101,748 US adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The overall PDI, healthful PDI (hPDI), and unhealthful PDI (uPDI) were constructed to qualify adherence to overall, healthy, and less healthy plant-based diets, respectively, with higher scores indicating better adherence. Multivariable Cox regression was used to compute hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was conducted to identify the potential effect modifiers. Results: Over a mean follow-up of 8.86 years, 421 pancreatic cancer cases occurred. Participants in the highest compared with the lowest quartiles of overall PDI had a lower risk of pancreatic cancer [HRquartile (4 versus 1): 0.74; 95% confidence interval (CI): 0.57, 0.96; P-trend = 0.023]. A stronger inverse association was observed for hPDI (HRquartile 4 versus 1: 0.56; 95% CI: 0.42, 0.75; P-trend < 0.001). Conversely, uPDI was positively associated with the risk of pancreatic cancer (HRquartile 4 versus 1: 1.38; 95% CI: 1.02, 1.85; P-trend = 0.012). Subgroup analyses revealed a stronger positive association for uPDI in participants with BMI <25 (HRquartile 4 versus 1: 3.22; 95% CI: 1.56, 6.65) than in those with BMI >= 25 (HRquartile 4 versus 1: 1.08; 95% CI: 0.78, 1.51) (P-interaction = 0.001). Conclusions: In this US population, adherence to a healthy plant-based diet confers a lower risk of pancreatic cancer, whereas adherence to a less healthy plant-based diet confers a higher risk. These findings highlight the importance of considering plant food quality in preventing pancreatic cancer."

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