Recent advances and application value of circRNA in neuroblastoma

作者全名："Wu, Ke; Tan, Juan; Yang, Chao"

作者地址："[Wu, Ke] Chongqing Med Univ, Dept Pharmacol, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China; [Tan, Juan; Yang, Chao] Chongqing Med Univ, Child Healthcare Dept, Childrens Hosp, Chongqing, Peoples R China; [Yang, Chao] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Childrens, Dept Pediat Surg Oncol,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,China In, Chongqing, Peoples R China"

通信作者："Yang, C (通讯作者)，Chongqing Med Univ, Child Healthcare Dept, Childrens Hosp, Chongqing, Peoples R China.; Yang, C (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Childrens, Dept Pediat Surg Oncol,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,China In, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000971658500001

JCR分区：Q2

影响因子：4.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：circRNA; neuroblastoma; pathogenesis; biomarkers; tumor targeted therapy

摘要："Neuroblastoma (NB) is children's most prevalent solid malignant tumor, accounting for 15% of childhood cancer mortality. Non-coding RNA is important in NB pathogenesis. As a newly identified non-coding RNA, abnormal regulation (abnormal up-regulation or down-regulation) of the circRNAs expression is implicated in the tumorigenesis of various tumors, including NB. CircRNAs primarily regulate the expression of microRNA (miRNA) target genes by microRNA (miRNA) sponge adsorption. Clinical evidence suggests that the expression of certain circRNAs is associated with the prognosis and clinical features of NB and hence may be exploited as a biomarker or therapeutic target. This review examines circRNAs that have been demonstrated to play a function in NB."

基金机构：　

基金资助正文：