Clinical application of F-18-FCH PET/CT in the diagnosis and treatment of hyperparathyroidism

作者全名："Liu, Shuang; Li, Mengdan; Pang, Hua; Zuo, Rui; Kong, Lingquan; Wang, Zhengjie; Li, Wenbo; Xia, Zhu; Wang, Dong; Xu, Lu"

作者地址："[Liu, Shuang; Li, Mengdan; Pang, Hua; Zuo, Rui; Wang, Zhengjie; Li, Wenbo; Xia, Zhu; Xu, Lu] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China; [Kong, Lingquan] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast Thyroid Surg, Chongqing, Peoples R China; [Wang, Dong] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound Med, Chongqing, Peoples R China"

通信作者："Xu, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000973747800001

JCR分区：Q2

影响因子：5.2

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：hyperparathyroidism; F-18-FCH PET; CT; quantitative study; diagnosis; imaging time selection

摘要："ObjectiveWe evaluated the difference in parathyroid visualization on F-18-FCH PET/CT images obtained at 5 and 60 min, and quantitatively analyzed the mode of FCH uptake at different time points, to determine the best imaging time for FCH PET/CT. MethodsThis retrospective study included 73 patients with hyperparathyroidism (HPT) who underwent F-18-FCH PET/CT imaging between December 2017 and December 2021. The diagnostic efficiency of 5- and 60-min dual time point imaging for the diagnosis of hyperparathyroidism and parathyroid adenoma and hyperplasia, were compared using visual and quantitative analyses. ResultsDual-time F-18-FCH PET/CT imaging visual analysis had diagnostic value for HPT. The receiver operating characteristic curve of PET/CT quantitative parameters for the diagnosis of HPT and lesions showed that the parathyroid/thyroid SUVmax ratio for 60-min imaging had a higher sensitivity and specificity (based on patient, sensitivity: 90.90% and specificity: 85.71%; based on focus, sensitivity: 83.06% and specificity: 85.71%) compared to that for 5-min imaging. PET/CT quantitative parameters can distinguish parathyroid adenoma and hyperplasia. The 60-min parathyroid SUVmax value had the highest diagnostic value (cutoff: 3.945; area under the curve: 0.783). ConclusionThe quantitative parameters of 60min F-18-FCH PET/CT have more advantages in aiding in the pathologica diagnosis and clinical treatment of HPT."

基金机构：Chongqing medical scientific research project [2021MSXM087]

基金资助正文：Funding This work is supported by Chongqing medical scientific research project (2021MSXM087).