Combination of Novel Therapies and New Attempts in Anaplastic Thyroid Cancer

作者全名："Li, Wenbo; Li, Yue; Li, Jia; Pang, Hua"

作者地址："[Li, Wenbo; Li, Yue; Li, Jia; Pang, Hua] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing 400016, Peoples R China"

通信作者："Pang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, Chongqing 400016, Peoples R China."

来源：TECHNOLOGY IN CANCER RESEARCH & TREATMENT

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000975358100001

JCR分区：Q3

影响因子：2.8

年份：2023

卷号：22

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Anaplastic thyroid cancer; multimodal therapy; molecular targeted therapy

摘要："Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, and it is rapidly falling without any effective therapeutic options. Although radical surgery, radiotherapy, and chemotherapy are performed on patients, the curative effect is suboptimal, and the survival rate is still poor. The discovery of altered gene pathways involved in this aggressive disease has advanced, but molecular targeted drugs targeting these pathways are still in clinical trials. To date, there is no effective way to treat this disease, so it is particularly urgent to find new treatments. At present, multimodal therapy is gradually being applied in clinical practice, which provides a new possibility for prolonging the survival time and improving the prognosis of anaplastic thyroid carcinoma. In this study, we retrospectively analyzed the current clinical multimodal therapy for patients with anaplastic thyroid cancer to evaluate its effect on improving the survival of patients with anaplastic thyroid cancer at different stages."

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