Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice

作者全名："Lu, Zhaohong; Wang, Fanghong; Xia, Yinyin; Cheng, Shuqun; Zhang, Jun; Qin, Xia; Tian, Xin; Wang, Bin; Qiu, Jingfu; Zou, Zhen; Jiang, Xuejun; Chen, Chengzhi"

作者地址："[Lu, Zhaohong; Wang, Fanghong; Xia, Yinyin; Cheng, Shuqun; Chen, Chengzhi] Chongqing Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Chongqing 400016, Peoples R China; [Zhang, Jun; Zou, Zhen] Chongqing Med Univ, Inst Life Sci, Mol Biol Lab Resp Dis, Chongqing 400016, Peoples R China; [Qin, Xia; Wang, Bin] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, Chongqing 400016, Peoples R China; [Tian, Xin] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Qiu, Jingfu] Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Lab Technol, Chongqing 400016, Peoples R China; [Zou, Zhen; Jiang, Xuejun; Chen, Chengzhi] Chongqing Med Univ, Res Ctr Environm & Human Hlth, Chongqing 400016, Peoples R China; [Jiang, Xuejun] Chongqing Med Univ, Ctr Expt Teaching Publ Hlth, Expt Teaching & Management Ctr, Chongqing 400016, Peoples R China; [Jiang, Xuejun] 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Chen, CZ (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Chongqing 400016, Peoples R China.; Zou, Z (通讯作者)，Chongqing Med Univ, Inst Life Sci, Mol Biol Lab Resp Dis, Chongqing 400016, Peoples R China.; Jiang, XJ (通讯作者)，1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000976014800001

JCR分区：Q1

影响因子：6.2

年份：2023

卷号：249

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Arsenite; Intestinal impairment; Neurobehavioral impairment; Gut-brain axis

摘要："Arsenite is a well-documented neurotoxic metalloid that widely distributes in the natural environment. However, it remains largely unclear how arsenite affects neurological function. Therefore, in this study, the healthy adult male mice were exposed to 0.5 mg/L and 5 mg/L arsenite through drinking water for 30 and 90 days, respec-tively. Our results showed that there was no significant alteration in the intestine and brain for 30 days exposure, but exposure to arsenite for 90 days significantly induced a reduction of locomotor activity and anxiety-like behavior, caused pathological damage and inflammatory responses in the brain and intestine. We also found that arsenite remarkably disrupted intestinal barrier integrity, decreased the levels of lysozyme and digestive enzymes. Intriguingly, chronic exposure to arsenite significantly changed the levels of gut-brain peptides. Taken together, this study provides meaningful insights that gut-brain communication may involve in the neuro-behavioral impairments of arsenite."

基金机构："National Natural Science Foundation of China [81602820, 81703187, 81903358, 82001378]; Chongqing Talents: Exceptional Young Talents Project [CQYC2020058650, CQYC2021058941]; Natural Science Foundation of Chongqing [cstc2021ycjh-bgzxm0105, cstc2020jcyj-msxmX0155, cstc2021jcyj-msxmX0141]; Research Program of Basic Research and Frontier Technology of Chongqing Yuzhong district [2020005]; young talent of Bayu scholar"

基金资助正文："This research was supported by National Natural Science Foundation of China (Grant Number: 81602820, 81703187, 81903358, 82001378), Chongqing Talents: Exceptional Young Talents Project (CQYC2020058650 and CQYC2021058941), Natural Science Foundation of Chongqing (cstc2021ycjh-bgzxm0105, cstc2020jcyj-msxmX0155 and cstc2021jcyj-msxmX0141). Research Program of Basic Research and Frontier Technology of Chongqing Yuzhong district (2020005). J.Z., Z.Z. and C.C were supported by young talent of Bayu scholar."