Changes of gut microbiota reflect the severity of major depressive disorder: a cross sectional study

作者全名："Hu, Xi; Li, Yifan; Wu, Jing; Zhang, Hanping; Huang, Yu; Tan, Xunmin; Wen, Lu; Zhou, Xingyu; Xie, Peijun; Olasunkanmi, Oluwatayo Israel; Zhou, Jingjing; Sun, Zuoli; Liu, Min; Zhang, Guofu; Yang, Jian; Zheng, Peng; Xie, Peng"

作者地址："[Hu, Xi; Li, Yifan; Wu, Jing; Zhang, Hanping; Huang, Yu; Tan, Xunmin; Wen, Lu; Zhou, Xingyu; Xie, Peijun; Olasunkanmi, Oluwatayo Israel; Zheng, Peng; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Hu, Xi; Li, Yifan; Wu, Jing; Zhang, Hanping; Huang, Yu; Tan, Xunmin; Wen, Lu; Zhou, Xingyu; Xie, Peijun; Zheng, Peng; Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhou, Jingjing; Sun, Zuoli; Liu, Min; Zhang, Guofu; Yang, Jian] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China; [Zhou, Jingjing; Sun, Zuoli; Liu, Min; Zhang, Guofu; Yang, Jian] Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China; [Zhou, Jingjing; Sun, Zuoli; Liu, Min; Zhang, Guofu; Yang, Jian] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China"

通信作者："Zheng, P; Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zheng, P; Xie, P (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China.; Yang, J (通讯作者)，Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China.; Yang, J (通讯作者)，Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China.; Yang, J (通讯作者)，Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000978258200003

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Disturbed gut microbiota is a potential factor in the pathogenesis of major depressive disorder (MDD), yet whether gut microbiota dysbiosis is associated with the severity of MDD remains unclear. Here, we performed shotgun metagenomic profiling of cross-sectional stool samples from MDD (n = 138) and healthy controls (n = 155). The patients with MDD were divided into three groups according to Hamilton Depression Rating Scale 17 (HAMD-17), including mild (n = 24), moderate (n = 72) and severe (n = 42) individuals, respectively. We found that microbial diversity was closely related to the severity of MDD. Compared to HCs, the abundance of Bacteroides was significantly increased in both moderate and severe MDD, while Ruminococcus and Eubacterium depleted mainly in severe group. In addition, we identified 99 bacteria species specific to severity of depression. Furthermore, a panel of microbiota marker comprising of 37 bacteria species enabled to effectively distinguish MDD patients with different severity. Together, we identified different perturbation patterns of gut microbiota in mild-to-severe depression, and identified potential diagnostic and therapeutic targets."

基金机构："Projects of International Cooperation and Exchanges NSFC [81820108015]; Natural Science Foundation Project of China [81971296, 82171523, 82201688, 82171526]; China Postdoctoral Science Foundation [2021MD703928, 2022MD713717]; CQMU Program for Youth Innovation in Future Medicine, Chongqing Science &Technology Commission [cstc2019 jcyjjqX0009, cstc2021jscx-msxm0026, cstc2021jscx-msxm0025]"

基金资助正文："This work was supported by the Projects of International Cooperation and Exchanges NSFC (81820108015), The Natural Science Foundation Project of China (81971296, 82171523, 82201688, 82171526), China Postdoctoral Science Foundation (2021MD703928, 2022MD713717), CQMU Program for Youth Innovation in Future Medicine, Chongqing Science & Technology Commission (cstc2019 jcyjjqX0009, cstc2021jscx-msxm0026, cstc2021jscx-msxm0025), Beijing Talents Project, Beijing Scholar 2021 Program."