ANALYSIS OF VASCULAR CHANGES OF FUNDUS IN BEHCET UVEITIS BY WIDEFIELD SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND FUNDUS FLUORESCEIN ANGIOGRAPHY

作者全名："Guo, Suo; Liu, Hui; Gao, Yu; Dai, Lingyu; Xu, Jing; Yang, Peizeng"

作者地址："[Guo, Suo; Liu, Hui; Gao, Yu; Dai, Lingyu; Xu, Jing; Yang, Peizeng] Chongqing Med Univ, Chongqing Eye Inst, Chongqing Branch, Chongqing Key Lab Ophthalmol,Affiliated Hosp 1,Mun, Chongqing, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China"

通信作者："Yang, PZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000978436500021

JCR分区：Q1

影响因子：3.3

年份：2023

卷号：43

期号：5

开始页：841

结束页：850

文献类型：Article

关键词：widefield optical coherence tomography angiography; Behcet uveitis; peripheral fundus

摘要："Purpose:To investigate vascular changes of fundus in quiescent Behcet uveitis (BU) based on widefield swept source optical coherence tomography angiography and fluorescein angiography (FA).Method:This case-control study included 33 patients with quiescent BU (57 eyes)and 35 healthy people (60 eyes) as the control. All participants underwent the widefield swept source optical coherence tomography angiography, and patients with BU additionally underwent the FA. The quantitative analysis of the widefield swept source optical coherence tomography angiography assessed the vessel density of nine anatomical locations in the fundus. Vascular leakage and retinal nonperfusion on FA were assessed in patients with BU.Results:Compared with the control group using Mann-Whitney U test, patients with BU had enlargement of foveal avascular zone (P = 0.005, P = 0.04, respectively) and decreased vessel density within a 300 mu m width around the foveal avascular zone (P = 0.001, P < 0.0001, respectively) both in the superficial and deep retina. Larger foveal avascular zone size and lower 300 mu m width around the foveal avascular zone were correlated with higher logarithm of the minimum angle of resolution best-corrected visual acuity in BU (P <= 0.003, P < 0.0001, respectively). Vessel density of choriocapillaris, as the most widely involved of all layers of the retina and choroid, was lower in six locations (P <= 0.03-0.0001) in the peripheral fundus of BU compared with the controls. Vascular leakage and retinal nonperfusion in the peripheral fundus were observed in 54.4% and 66.7% of the patients on FA.Conclusion:Fovea and peripheral fundus were prone to the damage of ischemia as evidenced by significantly decreased vessel density of capillaries. Combination of swept source optical coherence tomography angiography with FA could accurately evaluate the changes in the retinal and choroidal vasculature in BU."

基金机构：National Natural Science Foundation Key Program [81930023]; Key Project of Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0010]; Chongqing Out-standing Science Project; Chongqing Chief Medical Scientist Project; Chongqing Key Laboratory of Ophthalmology (CSTC) [2008CA5003]; Chongqing Science and Technology Platform and Base Construction Program [cstc2014ptsy10002]

基金资助正文："Supported in part by National Natural Science Foundation Key Program (81930023), Key Project of Chongqing Science and Technology Bureau (CSTC2021jscx-gksb-N0010), Chongqing Out-standing Science Project (2019), Chongqing Chief Medical Scientist Project (2018), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), and Chongqing Science and Technology Platform and Base Construction Program (cstc2014ptsy10002)."