"Effects of apolipoprotein E polymorphism on cerebral oxygen saturation, cerebral perfusion, and early prognosis after traumatic brain injury"

作者全名："Lin, Xun; Li, Qilin; Sun, Xiaochuan; Shi, Quanhong; Dan, Wei; Zhan, Yan; Deng, Bo; Xia, Yulong; Xie, Yanfeng; Jiang, Li"

作者地址："[Lin, Xun; Sun, Xiaochuan; Shi, Quanhong; Dan, Wei; Zhan, Yan; Deng, Bo; Xia, Yulong; Xie, Yanfeng; Jiang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China; [Li, Qilin] Youyang Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Xie, Yanfeng; Jiang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Xie, YF; Jiang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000978733300001

JCR分区：Q1

影响因子：5.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

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摘要："Objective To investigate the effects of the apolipoprotein E (APOE) gene on oxygen saturation and cerebral perfusion in the early stages of traumatic brain injury (TBI).Methods This study included 136 consecutive TBI patients and 51 healthy individuals. The APOE genotypes of all subjects were determined using quantitative fluorescence polymerase chain reaction (QF-PCR). Regional cerebral oxygen saturation (rScO2) of patients with TBI and normal subjects was monitored using near-infrared spectroscopy (NIRS). Computed tomography (CT) perfusion was used to obtain cerebral perfusion in patients with TBI and normal subjects.Results In the TBI group, the rScO2 of APOEe4 carriers (53.06 +/- 6.87%) was significantly lower than that of non-carriers (58.19 +/- 5.83%, p < 0.05). Meanwhile, the MTT of APOEe4 carriers (6.75 +/- 1.30 s) was significantly longer than that of non-carriers (5.87 +/- 1.00 s, p < 0.05). Furthermore, correlation analysis showed a negative correlation between rSCO2 and MTT in patients with TBI. Both the univariate and multifactorial logistic regression analyses revealed that APOE e4, hypoxia, MTT >5.75 s, Marshall CT Class, and GCS were independent risk factors for early poor prognosis in patients with TBI.Conclusion Both cerebral perfusion and cerebral oxygen were significantly impaired after TBI, and low cerebral perfusion and hypoxia were related to poor prognosis of patients with TBI. Compared with APOE e4 non-carriers, APOE e4 carriers not only had poorer cerebral perfusion and cerebral oxygen metabolism but also worse prognosis in the early stages of TBI. Furthermore, a negative correlation was observed between the rSCO2 and MTT levels. In addition, both CT perfusion scanning (CTP) and NIRS are reliable for monitoring the condition of patients with TBI in the neurological intensive care unit (NICU)."

基金机构：National Natural Science Foundation for Youth of China [81701226]; Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022MSXM041]

基金资助正文：This study was funded by the National Natural Science Foundation for Youth of China (no. 81701226) and Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2022MSXM041).