Advances in nanomaterial-based targeted drug delivery systems

作者全名："Cheng, Xiaoxiao; Xie, Qirong; Sun, Yang"

作者地址："[Cheng, Xiaoxiao; Xie, Qirong; Sun, Yang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Ultrasound,Chongqing Key Lab Ultrasound Mol I, Chongqing, Peoples R China"

通信作者："Sun, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Ultrasound,Chongqing Key Lab Ultrasound Mol I, Chongqing, Peoples R China."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000979669900001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：nanomaterials; nano-drug delivery system; surface modification; targeted delivery; EPR; blood brain barrier

摘要："Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases."

基金机构："Innovation Leaders Program of Chongqing Talents [CQYC20210303225]; Senior Medical Talents Program of Chongqing for Young and Middle-aged [2020-219]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [2022-26]"

基金资助正文："This study was financially supported by the Innovation Leaders Program of Chongqing Talents (Grant No. CQYC20210303225), Senior Medical Talents Program of Chongqing for Young and Middle-aged (2020-219), Program for Youth Innovation in Future Medicine, Chongqing Medical University (2022-26)."