Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma
作者全名："Huang, Tong; Xu, Xinzhi; Cheng, Chen; Wang, Jianxin; Yang, Liping"
作者地址："[Huang, Tong; Cheng, Chen; Wang, Jianxin] Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Xu, Xinzhi] Chongqing Univ, Dept Ultrasound, Canc Hosp, Chongqing 400030, Peoples R China; [Wang, Jianxin] Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 1, Harbin 150001, Peoples R China; [Yang, Liping] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China"
通信作者："Wang, JX (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Wang, JX (通讯作者)，Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 1, Harbin 150001, Peoples R China.; Yang, LP (通讯作者)，Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China."
来源：JOURNAL OF NANOBIOTECHNOLOGY
ESI学科分类：BIOLOGY & BIOCHEMISTRY
关键词：Uveal melanoma; Photothermal therapy; Photodynamic therapy; Dual-modal imaging; Nanomedicine
摘要："BackgroundUveal melanoma (UM) is adults' most common primary intraocular malignant tumor, prone to metastasis and high mortality. Eyeball enucleation commonly used in the clinic will lead to permanent blindness and mental disorders. Thus, new methods are urgently needed to diagnose and treat UM early to preserve patients' vision.Methods and resultsHerein, multifunctional nanoparticles (NPs) were synthesized by loading chlorin e6 (Ce6) in poly-lactic-co-glycolic acid (PLGA) NPs and wrapping Fe-III-tannic acid (Fe-III-TA) on the outside (Fe-III-TA/PLGA/Ce6, designated as FTCPNPs). Then, the synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antitumor effects of FTCPNPs excited by near-infrared (NIR) laser were evaluated. Moreover, we verified the mechanism of synergistic PTT/PDT leading to mitochondrial dysfunction and inducing tumor cell apoptosis. Additionally, FTCPNPs can be used as excellent magnetic resonance (MR)/photoacoustic (PA) imaging contrast agents, enabling imaging-guided cancer treatment. Finally, The NPs have good biological safety.ConclusionThis noninvasive NIR light-triggered cooperative phototherapy can easily penetrate eye tissue and overcome the disadvantage of limited penetration of phototherapy. Therefore, cooperative phototherapy is expected to be used in fundus tumors. This treatment model is applied to UM for the first time, providing a promising strategy and new idea for integrating the diagnosis and treatment of UM."