"Pattern of Antibiotic Prescriptions in Chinese Children, A Cross-Sectional Survey From 17 Hospitals Located Across 10 Provinces of China"

作者全名："Zhang, Jiaosheng; Ma, Xiang; Tang, Lanfang; Tian, Daiyin; Lin, Li; Li, Yanqi; Lu, Gen; Si, Ligang; Zhang, Wenshuang; Qian, Jing; Wu, Lijuan; Liu, Gang; Li, Wei; Cao, Qing; Wu, Keye; Zheng, Yuejie; Deng, Jikui; Yang, Yonghong"

作者地址："[Zhang, Jiaosheng; Deng, Jikui] Shenzhen Childrens Hosp, Dept Infect Dis, Shenzhen, Peoples R China; [Ma, Xiang] Shandong Univ, Jinan Childrens Hosp, Dept Resp, Jinan, Peoples R China; [Ma, Xiang] Shandong Univ, Childrens Hosp, Jinan, Peoples R China; [Tang, Lanfang] Zhejiang Univ, Childrens Hosp, Sch Med, Dept Resp, Hangzhou, Peoples R China; [Tian, Daiyin] Chongqing Med Univ, Childrens Hosp, Dept Resp, Chongqing, Peoples R China; [Lin, Li] Wenzhou Med Univ, Affiliated Hosp 2, Dept Resp, Wenzhou, Peoples R China; [Lin, Li] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China; [Li, Yanqi] Xian Childrens Hosp, Dept Resp, Xian, Peoples R China; [Lu, Gen] Guangzhou Women & Childrens Med Ctr, Dept Resp, Guangzhou, Peoples R China; [Si, Ligang] Haerbin Med Univ, Hosp 1, Dept Resp, Harbin, Peoples R China; [Zhang, Wenshuang] Tianjin Childrens Hosp, Dept Resp, Tianjin, Peoples R China; [Qian, Jing] Capital Inst Pediat, Childrens Hosp, Dept Resp, Beijing, Peoples R China; [Wu, Lijuan] Baoan Matern & Child Hlth Hosp, Clin Lab, Shenzhen, Peoples R China; [Liu, Gang] Capital Med Univ, Dept Infect Dis, Beijing Childrens Hosp, Beijing, Peoples R China; [Li, Wei] Jilin Univ, Hosp 1, Dept Pediat Resp, Changchun, Peoples R China; [Cao, Qing] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Infect Dis, Shanghai, Peoples R China; [Wu, Keye] Shenzhen Childrens Hosp, Dept Cardiothorac Surg, Shenzhan, Peoples R China; [Zheng, Yuejie] Shenzhen Childrens Hosp, Dept Resp, Shenzhen, Peoples R China; [Yang, Yonghong] Capital Med Univ, Shenzhen Childrens Hosp, Beijing Pediat Res Inst, Natl Ctr Childrens Hlth,Dept Internal Med,Beijin, Beijing, Peoples R China"

通信作者："Deng, JK (通讯作者)，Shenzhen Childrens Hosp, Dept Infect Dis, Shenzhen, Peoples R China.; Yang, YH (通讯作者)，Capital Med Univ, Shenzhen Childrens Hosp, Beijing Pediat Res Inst, Natl Ctr Childrens Hlth,Dept Internal Med,Beijin, Beijing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000980711800001

JCR分区：Q1

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：antibiotic; inpatients; pattern; children; China; AWaRe classification

摘要："ObjectivesUse of Broad-spectrum antibiotics is related closely to increasing antimicrobial resistance. Reports on antibiotic prescriptions for Chinese children were rare. We described the prescribing patterns of antibiotic prescriptions for Chinese children from 2017 to 2019 based on the Anatomical Therapeutic Chemical Classification (ATC classification); the Access, Watch, and Reserve (AWaRe) classification from the World Health Organization (WHO), and the Management of Antibiotic Classification in China. MethodsA 1-day point-prevalence survey (PPSs) on antibiotics prescribing for Chinese children was conducted in hospitalized children from 17 centers in 10 Chinese provinces from 1 September 2017 to 30 November 2019. ResultsA total of 4,982 antibiotic prescriptions for Chinese children were included in the analysis. There were 76 types of antibiotic agents in total, 22 (28.9%) of which accounted for 90% of all antibiotic prescriptions. The top-three antibiotics prescribed for children were azithromycin (684, 13.7%), ceftriaxone (508, 10.2%) and latamoxef (403, 8.1%). Third-generation cephalosporins (1,913, 38.4%) were the most commonly prescribed antibiotic classes. On the basis of the AWaRe classification, the Watch group antibiotics accounted for 76.3% and Access group antibiotics accounted for 12.1% of all antibiotic prescriptions. On the basis of the China classification, we showed that 26.5% of antibiotic prescriptions were in the Unrestricted group, 53.6% in the Restricted group, and 14.5% in the Special group. ConclusionThe proportion of antibiotics included in the Watch group and the Special group was high in children in China. The AWaRe classification and China classification for antibiotic prescriptions could be used to supply detailed data for antibiotic stewardship as a simple metric."

基金机构：Project of the Expert Committee on Clinical Application and Drug Resistance Evaluation of Antimicrobial Drugs of the National Health Commission [KJYWZWH-OT-02-2021-01]; Shenzhen Healthcare Research Project [SZLY2018016]; Shenzhen Fund for Guangdong Provincial High level Clinical Key Specialties [SZGSP012]

基金资助正文："This research was funded by Project of the Expert Committee on Clinical Application and Drug Resistance Evaluation of Antimicrobial Drugs of the National Health Commission (No. KJYWZWH-OT-02-2021-01), Shenzhen Healthcare Research Project (No. SZLY2018016), and Shenzhen Fund for Guangdong Provincial High level Clinical Key Specialties (No. SZGSP012). The sponsors had no any role in the study design, data collection, data analysis, data interpretation, writing of report, or decision to submit the article for publication."