A novel 25-ferroptosis-related gene signature for the prognosis of gliomas

作者全名："Peng, Xiaojiang; Liu, Chun; Li, Jing; Bao, Zeqing; Huang, Tao; Zeng, Lingfeng; He, Qixiong; Xue, Daojin"

作者地址："[Peng, Xiaojiang; Bao, Zeqing; He, Qixiong] Zhaoqing Med Coll, Zhaoqing, Peoples R China; [Liu, Chun] Nanjing Med Univ, Dept Neurosurg, Lianshui Peoples Hosp, Kangda Coll, Huaian, Peoples R China; [Li, Jing] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [Huang, Tao; Xue, Daojin] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Dept Neurosurg, Affiliated Hosp 2, Guangzhou, Peoples R China; [Zeng, Lingfeng] Chinese Univ Hong Kong, Dept Med, Hong Kong, Peoples R China"

通信作者："Xue, DJ (通讯作者)，Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Dept Neurosurg, Affiliated Hosp 2, Guangzhou, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000980896500001

JCR分区：Q2

影响因子：4.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ferroptosis; gene signature; prognosis; gliomas; bioinformatic

摘要："BackgroundFerroptosis is closely associated with cancer and is of great importance in the immune evasion of cancer. However, the relationship between ferroptosis and glioma is unclear. MethodsWe downloaded the expression profiles and clinical data of glioma from the GlioVis database and obtained the expression profiles of ferroptosis genes. A ferroptosis-related gene signature was developed for the prognosis of gliomas. ResultsWe screened out prognostic ferroptosis genes, named ferroptosis-related genes, by the Cox regression method. Based on these genes, we used unsupervised clustering to obtain two different clusters; the principal component analysis algorithm was applied to determine the gene score of each patient, and then all the patients were classified into two subgroups. Results showed that there exist obvious differences in survival between different clusters and different gene score subgroups. The prognostic model constructed by the 25 ferroptosis-related genes was then evaluated to predict the clinicopathological features of immune activity in gliomas. ConclusionThe ferroptosis-related genes play an important role in the malignant process of gliomas, potentially contributing to the development of prognostic stratification and treatment strategies."

基金机构：13th Chaoyang Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine [ZY2022YL28]; Guangzhou Municipal Science and Technology Bureau [202002030221]; Science and Technology Innovation Guidance Project of Zhaoqing Municipal Science and Technology Bureau [2021040308025]; 17th Bajian Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine [BJ2022YL06]

基金资助正文："This study was supported by the 13th Chaoyang Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (ZY2022YL28), the Startup Fund from Guangzhou Municipal Science and Technology Bureau (No. 202002030221), the Science and Technology Innovation Guidance Project of Zhaoqing Municipal Science and Technology Bureau (No. 2021040308025), and the 17th Bajian Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (BJ2022YL06)."