Epidemiological characteristics of respiratory viruses in hospitalized children during the COVID-19 pandemic in southwestern China

作者全名："Zhu, Lin; Luo, Tingting; Yuan, Yining; Yang, Shu; Niu, Chao; Gong, Ting; Wang, Xueer; Xie, Xiaohong; Luo, Jian; Liu, Enmei; Fu, Zhou; Tian, Daiyin"

作者地址："[Zhu, Lin; Luo, Tingting; Niu, Chao; Gong, Ting; Wang, Xueer; Xie, Xiaohong; Luo, Jian; Liu, Enmei; Fu, Zhou; Tian, Daiyin] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Yuan, Yining] Chengdu Med Coll, Sch Publ Hlth, Chengdu, Peoples R China; [Yang, Shu] Chengdu Univ Tradit Chinese Med, Coll Intelligent Med, Chengdu, Peoples R China"

通信作者："Tian, DY (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Resp Med, Minist Educ Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000981122000001

JCR分区：Q2

影响因子：5.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19; SARS-CoV-2; nonpharmaceutical interventions; epidemiology; pediatrics; respiratory virus

摘要："BackgroundMultinational studies have reported that the implementation of nonpharmaceutical interventions (NPIs) to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission coincided with the decline of other respiratory viruses, such as influenza viruses and respiratory syncytial virus. ObjectiveTo investigate the prevalence of common respiratory viruses during the coronavirus disease 2019 (COVID-19) pandemic. MethodsRespiratory specimens of children with lower respiratory tract infections (LRTIs) hospitalized at the Children's Hospital of Chongqing Medical University from January 1, 2018 to December 31, 2021 were collected. Seven common pathogens, including respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus A and B (Flu A, Flu B), and parainfluenza virus types 1-3 (PIV1-3), were detected by a multiplex direct immunofluorescence assay (DFA). Demographic data and laboratory test results were analyzed. Results1) A total of 31,113 children with LRTIs were enrolled, including 8141 in 2018, 8681 in 2019, 6252 in 2020, and 8059 in 2021.The overall detection rates decreased in 2020 and 2021 (P < 0.001). The detection rates of RSV, ADV, Flu A, PIV-1, and PIV-3 decreased when NPIs were active from February to August 2020, with Flu A decreasing most predominantly, from 2.7% to 0.3% (P < 0.05). The detection rates of RSV and PIV-1 resurged and even surpassed the historical level of 2018-2019, while Flu A continued decreasing when NPIs were lifted (P < 0.05). 2) Seasonal patterns of Flu A completely disappeared in 2020 and 2021. The Flu B epidemic was observed until October 2021 after a long period of low detection in 2020. RSV decreased sharply after January 2020 and stayed in a nearly dormant state during the next seven months. Nevertheless, the detection rates of RSV were abnormally higher than 10% in the summer of 2021. PIV-3 decreased significantly after the COVID-19 pandemic; however, it atypically surged from August to November 2020. ConclusionThe NPIs implemented during the COVID-19 pandemic affected the prevalence and seasonal patterns of certain viruses such as RSV, PIV-3, and influenza viruses. We recommend continuous surveillance of the epidemiological and evolutionary dynamics of multiple respiratory pathogens, especially when NPIs are no longer necessary."

基金机构："National Natural Science Foundation of China [81870012]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0063]"

基金资助正文："Funding This work was supported by the National Natural Science Foundation of China (Grant: 81870012) and Program for Youth Innovation in Future Medicine, Chongqing Medical University (Number: W0063)."