Effect of serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte ratio on pregnancy and neonatal outcomes in women undergoing ICSI cycle

作者全名："Huang, Li-Juan; Wan, Qi; Li, Tian; Lv, Xing-Yu; Geng, Li-Hong; He, Qi-Qi; Zhong, Zhao-Hui; Li, Yuan; Tang, Xiao-Jun"

作者地址："[Huang, Li-Juan; Zhong, Zhao-Hui; Tang, Xiao-Jun] Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Wan, Qi; Lv, Xing-Yu; Geng, Li-Hong; He, Qi-Qi; Li, Yuan] Xinan Gynecol Hosp, Chengdu 610011, Peoples R China; [Li, Tian] Chongqing Med Univ, Dept Reprod Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Tang, XJ (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Sch Publ Hlth, Chongqing 400016, Peoples R China.; Li, Y (通讯作者)，Xinan Gynecol Hosp, Chengdu 610011, Peoples R China."

来源：BMC PREGNANCY AND CHILDBIRTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000983852200003

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Progesterone on human chorionic gonadotropin trigger day; metaphase II oocyte (P; MII) ratio; Cut-off value; Pregnancy outcomes; Neonatal outcomes; ICSI

摘要："BackgroundThe serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte (P/MII) ratio might be a more predictable indicator of pregnancy and neonatal outcomes as compare to P/estradiol (E2) or P alone. Hence, we conducted a larger population study to compare the pregnancy and neonatal outcomes in the low and high P/MII ratio.MethodsA retrospective, single-center, larger population cohort study between January 2015 and August 2021. Calculate the threshold effect of P/MII ratio on clinical pregnancy rate according to the construct smooth curve fitting. Divide data into two groups by threshold for comparison.Results3566 fresh ICSI-ET cycles were included, in which 929 singleton delivery and 676 twin deliveries. Compare to P/MII <= 0.367 group, it indicated that the P/MII > 0.367 group had a lower clinical pregnancy rate and live birth rate, furthermore, a significantly higher rate of LBW and SGA were observed in the singleton and twin deliveries. No deleterious impact of high P/MII ratio on embryo quality and undesirable pregnancy outcomes was shown.ConclusionsWhen P/MII is higher than 0.367, may have adverse impacts on pregnancy and neonatal outcomes for ICSI cycle."

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