Detection of inguinal lymph nodes is promising for the diagnosis of periprosthetic joint infection

作者全名："Qin, Leilei; Zhao, Chen; Wang, Hai; Yang, Jianye; Chen, Li; Su, Xudong; Wei, Li; Zhang, Tao; Li, Jia; Jian, Changchun; Hu, Ning; Huang, Wei"

作者地址："[Qin, Leilei; Zhao, Chen; Wang, Hai; Yang, Jianye; Chen, Li; Su, Xudong; Wei, Li; Zhang, Tao; Jian, Changchun; Hu, Ning; Huang, Wei] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing, Peoples R China; [Qin, Leilei; Zhao, Chen; Yang, Jianye; Chen, Li; Su, Xudong; Wei, Li; Zhang, Tao; Hu, Ning; Huang, Wei] Chongqing Med Univ, Orthoped Lab, Fuling Cent Hosp, Chongqing, Peoples R China; [Wang, Hai; Li, Jia] Affiliated Chongqing Univ, Dept Orthopaed, Fuling Cent Hosp, Chongqing, Peoples R China; [Li, Jia] North Sichuan Med Coll, Dept Orthoped, Affiliated Hosp, Sichuan, Peoples R China; [Jian, Changchun] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed, Chongqing, Peoples R China"

通信作者："Hu, N; Huang, W (通讯作者)，Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing, Peoples R China.; Hu, N; Huang, W (通讯作者)，Chongqing Med Univ, Orthoped Lab, Fuling Cent Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000985248900001

JCR分区：Q2

影响因子：5.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：prosthetic joint infection; lymph nodes; lymphadenopathy; ultrasound; diagnosis

摘要："BackgroundLocalized inguinal lymphadenopathy often represents lower extremity pathogen infection, while normalized lymphadenopathy is associated with infection regression. We hypothesized that inguinal lymph nodes (LNs) were enlarged in Periprosthetic Joint Infection (PJI) patients and that normalized inguinal LNs would be a promising way to determine the timing of reimplantation. MethodsWe prospectively enrolled 176 patients undergoing primary and revision hip or knee arthroplasty. All patients underwent ultrasound examination of inguinal LNs preoperatively. The diagnostic value of inguinal LNs in PJI was evaluated by the receiver operating characteristic (ROC) curve. ResultsThe median level of inguinal LNs was 26mm in the revision for PJI group compared with 12 mm in the aseptic revision group (p< 0.0001). The size of the inguinal LNs well distinguishes PJI from aseptic failure (AUC= 0.978) compare with ESR (AUC= 0.707) and CRP (AUC= 0.760). A size of 19mm was determined as the optimal threshold value of the inguinal LNs for the diagnosis of PJI, with a sensitivity of 92% and specificity of 96%. ConclusionUltrasonic analysis of inguinal LNs is a valuable piece of evidence for the diagnosis of PJI and evaluation of persistent infection."

基金机构："National Natural Science Foundation of China [82072443, 81972069]; Youth Excellence Program of the First Affiliated Hospital of Chongqing Medical University [ZYRC2020-03]"

基金资助正文：Funding This work was supported by the National Natural Science Foundation of China (Grant number: 82072443 and 81972069) and The Youth Excellence Program of the First Affiliated Hospital of Chongqing Medical University (Grant number: ZYRC2020-03).