Engineered Biomimetic Copper Sulfide Nanozyme Mediates "Don't Eat Me" Signaling for Photothermal and Chemodynamic Precision Therapies of Breast Cancer

作者全名："Zhan, Zhu; Zeng, Weiqiong; Liu, Junzhao; Zhang, Liang; Cao, Yang; Li, Pan; Ran, Haitao; Wang, Zhigang"

作者地址："[Zhan, Zhu; Zeng, Weiqiong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China; [Zhan, Zhu; Liu, Junzhao; Zhang, Liang; Cao, Yang; Li, Pan; Ran, Haitao; Wang, Zhigang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Ultrasound Dept,Chongqing Key Lab Ultrasound Mol I, Chongqing 400016, Peoples R China"

通信作者："Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Ultrasound Dept,Chongqing Key Lab Ultrasound Mol I, Chongqing 400016, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000985779200001

JCR分区：Q1

影响因子：9.5

年份：2023

卷号：　

期号：　

开始页：　

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文献类型：Article; Early Access

关键词：CD47; cancer cell membrane; nanozyme; photothermal therapy; chemodynamic therapy

摘要："The rapid development of nanomedicine has brought hope and confidence to the precise treatment of tumors. However, the efficacy of nanoparticle-mediated therapy is severely limited due to phagocytosis and clearance by macrophages. CD47 is a well-documented '' don't eat me '' signaling molecule that binds to the SIRP alpha receptor on the macrophage surface, inhibiting the phagocytic behavior of the macrophages. In this study, CD47overexpressing cancer cell membranes were used to coat hollow copper sulfide nanoparticles. The nanoparticles were shown to have an extended circulatory half-life and to actively target breast cancer, leading to increased accumulation in the tumor tissue. An excellent photothermal therapeutic effect was produced by near infrared laser irradiation. At the same time, beta-lapachone within the nanoparticles generated large amounts of hydrogen peroxide in the tumor environment, which was then catalyzed by the copper sulfide nanozyme to cytotoxic hydroxyl radicals, exerting a chemodynamic therapeutic effect. This engineered biomimetic nanozyme, through the mediation of the '' don't eat me '' signal, achieved both photothermal and chemodynamic precision treatments of breast cancer, creating a new mode of safe and effective tumor treatment."

基金机构："National Natural Science Foundation of China [82172092]; Natural Science Foundation of Chongqing [cstc2021jcyj-bsh0006]; Postdoctoral Science Foundation of China [2020T130154ZX]; General Project of Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0015]; Health Commission of Chongqing, China; Remarkable Innovation-Clinical Research Project; Second Affiliated Hospital of Chongqing Medical University; First Batch of Key Disciplines on Public Health in Chongqing"

基金资助正文："The authors gratefully acknowledge the support of this research by the National Natural Science Foundation of China (82172092) , the Natural Science Foundation of Chongqing (cstc2021jcyj-bsh0006) , the Postdoctoral Science Foundation of China (2020T130154ZX) , the General Project of Chongqing Natural Science Foundation (cstc2020jcyj-msxmX0015) , Remarkable Innovation-Clinical Research Project, The Second Affiliated Hospital of Chongqing Medical University, and The First Batch of Key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China."