Improved selectivity of molecularly imprinted polymers based on the synergistic action of hydrogen bond and electrostatic interaction

作者全名："Hu, Ting; Zhao, Qianghong; Wang, Ming; Zhou, Kai; Xia, Zhining; Huang, Yike"

作者地址："[Hu, Ting; Zhao, Qianghong; Wang, Ming; Zhou, Kai; Xia, Zhining] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Zhao, Qianghong; Huang, Yike] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Zhou, Kai] Chongqing Univ, Analyt & Testing Ctr, Chongqing, Peoples R China"

通信作者："Xia, ZN (通讯作者)，Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China.; Huang, YK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：JOURNAL OF MOLECULAR RECOGNITION

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000985796800001

JCR分区：Q3

影响因子：2.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：diclofenac sodium; electrostatic interaction; hydrogen bond; molecularly imprinted polymers; synergistic action

摘要："Based on the synergistic action of hydrogen bond and electrostatic interaction, provided by methacrylic acid and 2-aminoethyl ester hydrochloride (FM2), respectively, novel molecularly imprinted polymers (SA-MIPs) were designed to improve its selective recognition ability. Diclofenac sodium (DFC) was chosen as the template molecule of this study. The interaction and their recognition sites between two functional monomers and templates were confirmed by nuclear magnetic resonance hydrogen spectroscopy. Because of the synergistic action of hydrogen bond and electrostatic interaction, the imprinting factor (IF) of SA-MIPs (IF = 2.26) is superior to the corresponding monofunctional monomer imprinting materials (IF = 1.52, 1.20) and the materials using two functional monomers with an only single type of interaction (IF = 1.54, 1.75). The results of selective adsorption experiments indicate that the selective recognition ability of SA-MIPs is significantly better than that of the other four MIPs, and the difference in selectivity coefficient for methyl orange is the largest between SA-MIPs and the MIPs only using FM2, which is about 70 times. In addition, x-ray photoelectron spectroscopy was used to verify the interaction between SA-MIPs and the template. This work and its explanation of the interaction mechanism at the molecular level will be helpful for the rational design of novel MIPs with higher selectivity. Besides, SA-MIPs have good adsorption performance (37.75 mg/g) for DFC in aqueous solutions, which could be used as potential adsorption materials for the effective removal of DFC in the aquatic environment."

基金机构："National Natural Science Foundation of China [22204013, 21974015]; Postdoctoral Science Foundation Project of Chongqing [cstc2021jcyj-bshX0224]"

基金资助正文："National Natural Science Foundation of China, Grant/Award Numbers: 22204013, 21974015;Postdoctoral Science Foundation Project of Chongqing, Grant/Award Number:cstc2021jcyj-bshX0224"