The microbiota-gut-brain axis in sleep disorders

作者全名："Wang, Zhe; Wang, Zhong; Lu, Tangsheng; Chen, Wenhao; Yan, Wei; Yuan, Kai; Shi, Le; Liu, Xiaoxing; Zhou, Xinyu; Shi, Jie; Vitiello, Michael V.; Han, Ying; Lu, Lin"

作者地址："[Wang, Zhe; Wang, Zhong; Yan, Wei; Yuan, Kai; Shi, Le; Liu, Xiaoxing; Lu, Lin] Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Inst Mental Hlth,NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China; [Lu, Tangsheng; Han, Ying; Lu, Lin] Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China; [Lu, Tangsheng; Han, Ying; Lu, Lin] Peking Univ, Beijing Key Lab Drug Dependence, Beijing 100191, Peoples R China; [Chen, Wenhao] Zhejiang Univ, Affiliated Hosp 1, Dept Psychiat, Sch Med, Hangzhou 310003, Peoples R China; [Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Vitiello, Michael V.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA; [Lu, Lin] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China; [Lu, Lin] Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China"

通信作者："Lu, L (通讯作者)，Peking Univ Sixth Hosp, Inst Mental Hlth, 51 Huayuanbei Rd, Beijing 100191, Peoples R China.; Han, Y (通讯作者)，Peking Univ, Natl Inst Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China.; Han, Y (通讯作者)，Peking Univ, Beijing Key Lab Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China."

来源：SLEEP MEDICINE REVIEWS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000986580800001

JCR分区：Q1

影响因子：10.5

年份：2022

卷号：65

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Sleep; Sleep disorders; Sleep disturbances; Sleep-microbiome interaction; Microbiota-gut-brain axis; Interventions

摘要："Sleep is a complex physiological process and is a critical determinant of physical and mental health. In the past decades, significant progress has been made in understanding the neural mechanisms of sleep and awakening. However, the initiation and maintenance of the sleep-wake cycle is regulated not only by the central system but is also affected by signals from peripheral tissues. Growing evidence shows that the microbiota-gut-brain axis contributes to the regulation of sleep behavior both directly and indirectly and may play a critical role in the etiology and pathogenesis of sleep disorders. Sleep deprivation leads to dysfunction of gut microbiota and sleep disorders are accompanied by altered gut microbiota composition. In this review, we describe the bidirectional relationships between sleep and gut microbiota and summarize the abnormal characteristics of gut bacteria in distinct conditions including sleep disturbances, sleep disorders and sleep disorders comorbid with neuropsychiatric disorders. We also examine the potential routes of microbiota-gut-brain axis in sleep and gut microbiome interactions, including metabolic, immune, and neural pathways, and propose microbiota-targeted interventions for improving sleep. Manipulating gut microbiota may be a promising avenue for the development of novel interventions for sleep disorders. (c) 2022 Elsevier Ltd. All rights reserved."

基金机构：Chinese National Programs for Brain Science and Brain-like Intelligence Technology [2021ZD0200800]; PKU-Baidu Fund [2020BD011]

基金资助正文："This work was supported in part by the Chinese National Programs for Brain Science and Brain-like Intelligence Technology (no. 2021ZD0200800), and PKU-Baidu Fund (no. 2020BD011)."