Platelet distribution width and the risk of unexplained recurrent pregnancy loss: a meta-analysis

作者全名："Shi, Yan; Xu, Dongmei"

作者地址："[Shi, Yan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 400010, Peoples R China; [Xu, Dongmei] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, 120 Longshan Rd, Chongqing 400010, Peoples R China"

通信作者："Xu, DM (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, 120 Longshan Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000994723900002

JCR分区：Q2

影响因子：3.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Unexplained recurrent pregnancy loss; Platelet distribution width; Risk factor; Platelet function; Meta-analysis

摘要："ObjectiveChanges of platelet distribution width (PDW) have been observed in women with unexplained recurrent pregnancy loss (URPL). However, relevant previous studies showed inconsistent results. We performed a meta-analysis to comprehensively evaluate the association between PDW and URPL.MethodsObservational studies reporting the difference of PDW between women with and without URPL were retrieved by searching PubMed, Embase, Web of Science, Wanfang, and CNKI. A random-effect model was used to pool the results by incorporating potential heterogeneity.ResultsEleven case-control studies with 1847 women with URPL and 2475 healthy women were included. Age was matched for all studies between cases and controls. Pooled results showed women with URPL had significantly increased level of PDW (mean difference [MD]: 1.54%, 95% CI: 1.04 to 2.03, p < 0.05; I-2 =77%). Subgroup analysis showed consistent result for URPL defined as >= 2 (MD: 1.45%, p = 0.003) and >= 3 (MD: 1.61%, p < 0.001) failed clinical pregnancies, and in studies compared to women with normal pregnancy (MD: 2.02%, p < 0.001) and non-pregnant healthy women (MD: 1.34%, p < 0.001). Results of the meta-analysis also showed that increment of PDW was associated with higher odds of URPL (per 1 unit, odds ratio: 1.26, 95% CI: 1.17 to 1.35, p < 0.001; I-2 = 0%).ConclusionsWomen with URPL had significantly increased levels of PDW compared to healthy women without URPL, which suggest that higher PDW may predict the risk of URPL."

基金机构：Application of aspirin or low molecular weight heparin in the treatment of unex-plained recurrent early pregnancy failure [2021MSXM173]

基金资助正文：This study was supported by the program named "Application of aspirin or low molecular weight heparin in the treatment of unex-plained recurrent early pregnancy failure" (2021MSXM173).