"Noninvasive Prediction of Immune Rejection After Liver Transplantation with T cell immunoglobulin domain, and mucin domain-3"

作者全名："Qin, Li; Zheng, Weixiong; Jiang, Shiming; Tang, Hao; Cai, Meng; Chen, Anke; Chen, Yong"

作者地址："[Qin, Li; Zheng, Weixiong; Jiang, Shiming; Tang, Hao; Cai, Meng; Chen, Anke; Chen, Yong] Chongqing Med Univ, Chongqing, Peoples R China"

通信作者："Chen, Y (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：TRANSPLANTATION PROCEEDINGS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001005421300031

JCR分区：Q4

影响因子：0.9

年份：2022

卷号：54

期号：7

开始页：1881

结束页：1886

文献类型：Article

关键词：　

摘要："Background. T cell immunoglobulin domain, and mucin domain-3 (Tim-3) is associated with immunosuppression, immune tolerance, and rejection after organ transplantation, but there are no reports of rejection after human liver transplantation. This study aimed to detect Tim-3 expression after liver transplantation to determine whether Tim-3 can be used as a noninvasive index to predict immune rejection. Methods. Quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay were performed on healthy people and patients with liver transplantation to detect Tim-3 and cytokines. Hepatic biochemical test was used to detect liver function. The study conforms to the provisions of the Declaration of Helsinki and Istanbul. Results. The expression of Tim-3, alanine aminotransferase, and aspartate aminotransferase increased first and then decreased, whereas the cytokines showed upward trend. There was no significant difference in the expression of Tim-3 between preoperative patients and normal people (P >.05), whereas the expression of Tim-3 was significantly higher on the third day after operation than that before operation (P <.05). The expression of Tim-3, alanine aminotransferase, and aspartate aminotransferase peaked only once in most liver transplantation patients, but there were 3 patients that were exceptions. Conclusions. Tim-3 could be used as a potential biomarker to predict rejection after liver transplantation."

基金机构：Chongqing Municipal Health and Health Committee [2018MSXM031]

基金资助正文：This project was granted financial support from Chongqing Municipal Health and Health Committee (Grant No.2018MSXM031).