"COVID-19 vaccine coverage, safety, and perceptions among patients with diabetes mellitus in China: a cross-sectional study"

作者全名："Li, Haolong; Ping, Fan; Li, Xiaomeng; Wang, Zhihong; Xiao, Jianzhong; Jiang, Hongwei; Xue, Yaoming; Quan, Jinxing; Yao, Hebin; Zheng, Xianling; Chen, Yanming; Li, Yufeng; Yu, Xiaohua; Xu, Lingling; Feng, Xinxin; Wang, Siyu; Li, Yongzhe; Xiao, Xinhua"

作者地址："[Li, Haolong; Li, Xiaomeng; Feng, Xinxin; Wang, Siyu; Li, Yongzhe] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Lab, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China; [Ping, Fan; Xiao, Xinhua] Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China; [Li, Xiaomeng] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Med Res Ctr, Beijing, Peoples R China; [Wang, Zhihong] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China; [Xiao, Jianzhong] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Sch Clin Med, Dept Endocrinol, Beijing, Peoples R China; [Jiang, Hongwei] Henan Univ Sci & Technol, Coll Clin Med, Affiliated Hosp 1, Luoyang, Peoples R China; [Xue, Yaoming] Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China; [Quan, Jinxing] Gansu Prov Peoples Hosp, Dept Endocrinol, Lanzhou, Gansu, Peoples R China; [Yao, Hebin] Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Endocrinol, Beijing, Peoples R China; [Zheng, Xianling] Handan Cent Hosp, Dept Endocrinol, Handan, Peoples R China; [Chen, Yanming] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangdong Prov Key Lab Diabetol, Guangzhou, Guangdong, Peoples R China; [Li, Yufeng] Capital Med Univ, Dept Endocrinol, Beijing, Peoples R China; [Yu, Xiaohua] Liaoyang Cent Hosp, Dept Endocrinol, Liaoyang, Liaoning, Peoples R China; [Xu, Lingling] Southern Med Univ, ShenZhen Hosp, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China"

通信作者："Li, YZ (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Lab, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China.; Xiao, XH (通讯作者)，Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001006263600001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：diabetes mellitus; COVID-19; vaccine; vaccine uptake; China

摘要："AimsDiabetes mellitus (DM), one of the most common chronic diseases in China, is a risk factor for SARS-COV-2 infection and poor prognosis of COVID-19. The COVID-19 vaccine is one of the key measures to control the pandemic. However, the actual coverage of COVID-19 vaccination and associated factors remain unclear among DM patients in China. We conducted this study to investigate the COVID-19 vaccine coverage, safety, and perceptions among patients with DM in China. MethodsA cross-sectional study of a sample of 2200 DM patients from 180 tertiary hospitals in China was performed using a questionnaire developed through the Wen Juan Xing survey platform to collect information regarding their coverage, safety, and perceptions of COVID-19 vaccination. A multinomial logistic regression analysis model was performed to determine any independent relationships with COVID-19 vaccination behavior among DM patients. ResultsIn total, 1929 (87.7%) DM patients have received at least one dose COVID-19 vaccine, and 271 (12.3%) DM patients were unvaccinated. In addition, 65.2% (n = 1434) were booster vaccinated against COVID-19, while 16.2% (n = 357) were only fully vaccinated and 6.3% (n = 138) were only partially vaccinated. The prevalence of adverse effects after the first dose of vaccine, the second dose of vaccine, and the third dose of vaccine were 6.0%, 6.0%, and 4.3% respectively. Multinomial logistic regression analysis showed that DM patients complicated with immune and inflammatory diseases (partially vaccinated: OR = 0.12; fully vaccinated: OR = 0.11; booster vaccinated: OR = 0.28), diabetic nephropathy (partially vaccinated: OR = 0.23; fully vaccinated: OR = 0.50; booster vaccinated: OR = 0.30), and perceptions on the safety of COVID-19 vaccine (partially vaccinated: OR = 0.44; fully vaccinated: OR = 0.48; booster vaccinated: OR = 0.45) were all associated with the three of vaccination status. ConclusionThis study showed that higher proportion of COVID-19 vaccine coverage among patients with DM in China. The concern about the safety of the COVID-19 vaccine affected the vaccine behavior in patients with DM. The COVID-19 vaccine was relatively safe for DM patients due to all side effects were self-limiting."

基金机构：Beijing Natural Science Foundation [M23008]; National Key Research and Development Program of China [2018YFE0207300]; Beijing Municipal Science & Technology Commission [Z211100002521021]; National High Level Hospital Clinical Research Funding [2022-PUMCH-B-124]; Beijing Key Clinical Specialty for Laboratory Medicine - Excellent Project [ZK201000]

基金资助正文："Funding This work was supported by Beijing Natural Science Foundation (M23008), the National Key Research and Development Program of China (2018YFE0207300), Beijing Municipal Science & Technology Commission (Z211100002521021), the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-124). This work is supported by Beijing Key Clinical Specialty for Laboratory Medicine - Excellent Project (No. ZK201000)."