Portable Handheld "SkinPen" Loaded with Biomaterial Ink for In Situ Wound Healing

作者全名："Zhou, Fuyuan; Xin, Liangjing; Wang, Shuya; Chen, Kaiwen; Li, Dize; Wang, Si; Huang, Yuanding; Xu, Chuanhang; Zhou, Mengjiao; Zhong, Wenjie; Wang, Huanan; Chen, Tao; Song, Jinlin"

作者地址："[Zhou, Fuyuan; Xin, Liangjing; Li, Dize; Wang, Si; Huang, Yuanding; Xu, Chuanhang; Zhou, Mengjiao; Zhong, Wenjie; Chen, Tao; Song, Jinlin] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Zhou, Fuyuan; Xin, Liangjing; Li, Dize; Wang, Si; Huang, Yuanding; Xu, Chuanhang; Zhou, Mengjiao; Zhong, Wenjie; Chen, Tao; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Zhou, Fuyuan; Xin, Liangjing; Li, Dize; Wang, Si; Huang, Yuanding; Xu, Chuanhang; Zhou, Mengjiao; Zhong, Wenjie; Chen, Tao; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [Wang, Shuya; Chen, Kaiwen; Wang, Huanan] Key State Lab Fine Chem, Dalian 116024, Peoples R China; [Wang, Shuya; Chen, Kaiwen; Wang, Huanan] Dalian Univ Technol, Sch Bioengn, Dalian 116024, Peoples R China"

通信作者："Chen, T; Song, JL (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China.; Chen, T; Song, JL (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China.; Chen, T; Song, JL (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China.; Wang, HA (通讯作者)，Key State Lab Fine Chem, Dalian 116024, Peoples R China.; Wang, HA (通讯作者)，Dalian Univ Technol, Sch Bioengn, Dalian 116024, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001008219100001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：15

期号：23

开始页：27568

结束页：27585

文献类型：Article

关键词：GelMA; bioactive glass; in situ bioprinting; ultrasound; diabetes

摘要："In situ bioprinting has emerged as an attractive toolfor directlydepositing therapy ink at the defective area to adapt to the irregularwound shape. However, traditional bioprinting exhibits an obviouslimitation in terms of an unsatisfactory bioadhesive effect. Here,a portable handheld bioprinter loaded with biomaterial ink is designedand named ""SkinPen"". Gelatin methacrylate (GelMA) andCu-containing bioactive glass nanoparticles (Cu-BGn) serve as themain components to form the hydrogel ink, which displays excellentbiocompatibility and antibacterial and angiogenic properties. Moreimportantly, by introducing ultrasound and ultraviolet in a sequentialprogrammed manner, the SkinPen achieves in situ instant gelation andamplified (more than threefold) bioadhesive shear strength. It issuggested that ultrasound-induced cavitation and the resulting topologicalentanglement contribute to the enhanced bioadhesive performance together.Combining the ultrasound-enhanced bioadhesion with the curative roleof the hydrogel, the SkinPen shows a satisfactory wound-healing effectin diabetic rats. Given the detachable property of the SkinPen, thewhole device can be put in a first-aid kit. Therefore, the applicationscenarios can be expanded to many kinds of accidents. Overall, thiswork presents a portable handheld SkinPen that might provide a facilebut effective approach for clinical wound management."

基金机构："National Natural Science Foundation of China [32071362, U22A20314, 82201075]; National Key R&D of Program of China [2022YFC2504200]; Distinguished Young Scholars of Chongqing [CSTB2022NSCQ-JQX0012]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 32071362, U22A20314, 82201075), National Key R&D of Program of China (Grant No. 2022YFC2504200), and Distinguished Young Scholars of Chongqing (CSTB2022NSCQ-JQX0012)."