National Brain Tumour Registry of China (NBTRC) statistical report of primary brain tumours diagnosed in China in years 2019-2020

作者全名："Xiao, Dan; Yan, Changxiang; Li, Deling; Xi, Tianshu; Liu, Xianzhi; Zhu, Dan; Huang, Guodong; Xu, Jianguo; He, Zhengwen; Wu, Anhua; Ma, Chiyuan; Long, Jiang; Shu, Kai; Ji, Hongming; Wang, Ning; Chen, Gang; Yang, Jiankai; Ma, Hui; Li, Zhiyong; Sun, Xiaochuan; Qu, Yan; Liu, Zhixiong; Jiang, Xiaofan; Tian, Chunlei; Ni, Shilei; Zhan, Renya; Chen, Liwen; Ge, Ming; Wang, Maode; Jiang, Xiaobing; Guo, Geng; Han, Zhenmin; Zhang, Chuan; Zhang, Tingrong; Dou, Changwu; Chu, Liangzhao; Wang, Pengcheng; Shao, Junfei; Wu, Xiyue; Yu, Ju; Wang, Yu; Wu, Nan; Zhang, Rui; Zhang, Mingming; Hong, Yong; Gao, Jianzhong; Li, Yunqian; Pan, Yawen; Zhao, Bing; Ji, Nan; Shan, Guangliang; Patel, Chirag B.; Jia, Wang; Zhang, Liwei"

作者地址："[Xiao, Dan; Li, Deling; Xi, Tianshu; Jia, Wang; Zhang, Liwei] China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China; [Yan, Changxiang] Capital Med Univ, Sanbo Brain Hosp, Dept Neurosurg, Beijing, Peoples R China; [Li, Deling; Jia, Wang; Zhang, Liwei] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China; [Li, Deling; Jia, Wang; Zhang, Liwei] Beijing Neurosurg Inst, Beijing, Peoples R China; [Liu, Xianzhi] Zhengzhou Univ, Dept Neurosurg, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Zhu, Dan] Guangdong 999 Brain Hosp, Dept Neurosurg, Guangzhou, Peoples R China; [Huang, Guodong] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Neurosurg, Shenzhen, Peoples R China; [Huang, Guodong] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Key Lab Neurosurg, Shenzhen, Peoples R China; [Xu, Jianguo] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Peoples R China; [He, Zhengwen] Cent South Univ, Hunan Canc Hosp, Dept Neurosurg, Changsha, Peoples R China; [He, Zhengwen] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China; [Wu, Anhua] China Med Univ, Dept Neurosurg, Hosp 1, Shenyang, Peoples R China; [Ma, Chiyuan] Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing, Peoples R China; [Long, Jiang] Kunming Med Univ, Dept Neurosurg, Affiliated Hosp 1, Kunming, Peoples R China; [Shu, Kai] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan, Peoples R China; [Ji, Hongming] Shanxi Med Univ, Dept Neurosurg, Shanxi Prov Peoples Hosp, Taiyuan, Peoples R China; [Wang, Ning] Harbin Med Univ, Dept Neurosurg, Affiliated Hosp 1, Harbin, Peoples R China; [Chen, Gang] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou, Peoples R China; [Chen, Gang] Soochow Univ, Affiliated Hosp 1, Brain & Nerve Res Lab, Suzhou, Peoples R China; [Yang, Jiankai] Hebei Med Univ, Dept Neurosurg, Hosp 2, Shijiazhuang, Peoples R China; [Ma, Hui] Ningxia Med Univ, Dept Neurosurg, Gen Hosp, Yinchuan, Peoples R China; [Li, Zhiyong] Southern Med Univ, Nanfang Hosp, Dept Neurosurg, Guangzhou, Peoples R China; [Sun, Xiaochuan] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [Qu, Yan] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian, Peoples R China; [Liu, Zhixiong] Cent South Univ, Dept Neurosurg, Xiangya Hosp, Changsha, Peoples R China; [Jiang, Xiaofan] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Peoples R China; [Tian, Chunlei] Three Gorges Univ, Yichang Cent Peoples Hosp, Inst Neurosurg, Dept Neurosurg, Yichang, Peoples R China; [Tian, Chunlei] Three Gorges Univ, Clin Med Coll 1, Yichang, Peoples R China; [Ni, Shilei] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Neurosurg, Jinan, Peoples R China; [Ni, Shilei] Shandong Univ, Inst Brain & Brain Inspired Sci, Cheeloo Coll Med, Jinan, Peoples R China; [Zhan, Renya] Zhejiang Univ, Affiliated Hosp 1, Dept Neurosurg, Sch Med, Hangzhou, Peoples R China; [Chen, Liwen] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurosurg, Guangzhou, Peoples R China; [Ge, Ming] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Neurosurg, Beijing, Peoples R China; [Wang, Maode] Xi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian, Peoples R China; [Jiang, Xiaobing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan, Peoples R China; [Guo, Geng] Shanxi Med Univ, Hosp 1, Dept Neurosurg, Taiyuan, Peoples R China; [Han, Zhenmin] Chifeng Univ, Dept Neurosurg, Affiliated Hosp, Chifeng, Peoples R China; [Zhang, Chuan] Tianjin Med Univ Gen Hosp, Dept Neurosurg, Tianjin, Peoples R China; [Zhang, Tingrong] Xinjiang Med Univ, Dept Neurosurg, Affiliated Hosp 1, Urumqi, Peoples R China; [Dou, Changwu] Inner Mongolia Med Univ, Dept Neurosurg, Affiliated Hosp, Hohhot, Peoples R China; [Chu, Liangzhao] Guizhou Med Univ, Dept Neurosurg, Affiliated Hosp, Guiyang, Peoples R China; [Wang, Pengcheng] Hainan Prov Peoples Hosp, Dept Neurosurg, Haikou, Peoples R China; [Shao, Junfei] Nanjing Med Univ, Dept Neurosurg, Wuxi Peoples Hosp, Wuxi, Peoples R China; [Wu, Xiyue] Fujian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Fuzhou, Peoples R China; [Yu, Ju] Soochow Univ, Dept Neurosurg, Affiliated Hosp 2, Suzhou, Peoples R China; [Wang, Yu] Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Neurosurg, Shanghai, Peoples R China; [Wu, Nan] Univ Chinese Acad Sci, Chongqing Hosp, Chongqing Gen Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Zhang, Rui] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Neurosurg, Jinan, Peoples R China; [Zhang, Mingming] Cent South Univ, Dept Neurosurg, Xiangya Hosp 2, Changsha, Peoples R China; [Hong, Yong] Chengde Cent Hosp, Dept Neurosurg, Chengde, Peoples R China; [Gao, Jianzhong] First Hosp Yulin, Dept Neurosurg, Yulin, Peoples R China; [Li, Yunqian] First Hosp Jilin Univ, Dept Neurosurg, Changchun, Peoples R China; [Pan, Yawen] Lanzhou Univ, Dept Neurosurg, Hosp 2, Lanzhou, Peoples R China; [Zhao, Bing] Anhui Med Univ, Dept Neurosurg, Affiliated Hosp 2, Hefei, Peoples R China; [Shan, Guangliang] Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Sch Basic Med,Dept Epidemiol & Stat, Beijing, Peoples R China; [Patel, Chirag B.] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX USA"

通信作者："Zhang, LW (通讯作者)，China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China.; Zhang, LW (通讯作者)，Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China.; Zhang, LW (通讯作者)，Beijing Neurosurg Inst, Beijing, Peoples R China."

来源：LANCET REGIONAL HEALTH-WESTERN PACIFIC

ESI学科分类：　

WOS号：WOS:001028034500001

JCR分区：Q1

影响因子：7.1

年份：2023

卷号：34

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Brain tumor; Registry; Distribution; China

摘要："Background The lack of a well-designed brain tumour registry with standardized pathological diagnoses in underdeveloped countries hinders the ability to compare epidemiologic data across the globe. The National Brain Tumour Registry of China (NBTRC), created in January 2018, is the first multi-hospital-based brain tumour registry in China. Patient data reported to the NBTRC in years 2019-2020 were assessed.Methods Tumour pathology was based on the 2016 World Health Organization (WHO) classification of tumours of the central nervous system and ICD-O-3. The anatomical site was coded per the Surveillance, Epidemiology, and End Results (SEER) solid tumour module (version of July 2019). The cases were tabulated by histology and anatomical site. Categorical variables were reported as numbers (percentages). The distribution of tumours by age (0-14, 15-19, 20-39, 40-64, and 65+ years) was analysed.Findings There were a total of 25,537 brain tumours, foremost among them meningioma (23.63%), followed by tumours of the pituitary (23.42%), and nerve sheath tumours (9.09%). Glioblastoma, the most common and lethal form of primary brain cancer in adults, represented 8.56% of all cases. Of note, 6.48% of the malignant tumours were located in the brain stem. The percentage of malignant brain tumours decreased with increasing age, 24.08% in adults (40+ years), 30.25% in young adults (20-39 years), 35.27% in adolescents (15-19 years), and 49.83% in children (0-14 years). Among the 2107 paediatric patients, the most common sites were ventricle (17.19%), brainstem (14.03%), pituitary and craniopharyngeal duct (13.4%), and cerebellum (12.3%), a distribution that differed from that of the entire cohort. The histology distribution was also unique in children, with glioblastoma much less incident compared to the whole cohort (3% vs. 8.47%, p < 0.01). 58.80% of all patients chose higher-level neurosurgical hospitals outside of their province of residence. The median in-hospital length of stay (LOS) for the various pathologies ranged from 11 to 19 days.Interpretation The histological and anatomical site distribution of brain tumours in the NBTRC was statistically different in the subgroup of children (0-14 years). Patient choice of pursuing trans-provincial treatment was common and the in-hospital LOS was longer compared to that reported in similar European and American patient populations, which merits further attention.Funding The National Key Research and Development Program of China (2015BAI12B04, 2013BAI09B03, 2014BAI04B01, and 2021YFF1201104) and Chinese National Natural Science Foundation of China (81971668).Copyright & COPY; 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构："National Key Research and Development Program of China [2015BAI12B04, 2013BAI09B03, 2014BAI04B01, 2021YFF1201104]; Chinese National Natural Science Foundation of China [81971668]"

基金资助正文："The National Key Research and Development Program of China (2015BAI12B04, 2013BAI09B03, 2014BAI04B01, and 2021YFF1201104) and Chinese National Natural Science Foundation of China (81971668)."