Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics

作者全名："Li, Wenbin; Lei, Du; Tallman, Maxwell J.; Welge, Jeffrey A.; Blom, Thomas J.; Fleck, David E.; Klein, Christina C.; Adler, Caleb M.; Patino, L. Rodrigo; Strawn, Jeffrey R.; Gong, Qiyong; Sweeney, John A.; DelBello, Melissa P."

作者地址："[Li, Wenbin; Gong, Qiyong; Sweeney, John A.] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu 610000, Sichuan, Peoples R China; [Li, Wenbin; Tallman, Maxwell J.; Welge, Jeffrey A.; Blom, Thomas J.; Fleck, David E.; Klein, Christina C.; Adler, Caleb M.; Strawn, Jeffrey R.; Sweeney, John A.; DelBello, Melissa P.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Div Bipolar Disorders Res, Coll Med, Cincinnati, OH 45267 USA; [Li, Wenbin] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Zhengzhou 450052, Henan, Peoples R China; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Gong, Qiyong] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu, Sichuan, Peoples R China"

通信作者："Lei, D (通讯作者)，Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China.; Gong, QY (通讯作者)，Sichuan Univ, West China Hosp, Huaxi MR Res Ctr, Dept Radiol, Chengdu, Sichuan, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001028975100001

JCR分区：Q1

影响因子：6.6

年份：2023

卷号：338

期号：　

开始页：312

结束页：320

文献类型：Article

关键词：BD; ADHD; Psychotic symptoms; Structural MRI; Cortical thickness; Subcortical gray matter

摘要："Objectives: To characterize the neuroanatomy of BD in youth and its correlation to clinical characteristics. Methods: The current study includes a sample of 105 unmedicated youth with first-episode BD, aged between 10.1 and 17.9 years, and 61 healthy comparison adolescents, aged between 10.1 and 17.7 years, who were matched for age, race, sex, socioeconomic status, intelligence quotient (IQ), and education level. T1-weighted magnetic resonance imaging (MRI) images were obtained using a 4 T MRI scanner. Freesurfer (V6.0) was used to preprocess and parcellate the structural data, and 68 cortical and 12 subcortical regions were considered for statistical comparisons. The relationship between morphological deficits and clinical and demographic characteristics were evaluated using linear models. Results: Compared with healthy youth, youth with BD had decreased cortical thickness in frontal, parietal, and anterior cingulate regions. These youth also showed decreased gray matter volumes in 6 of the 12 subcortical regions examined including thalamus, putamen, amygdala and caudate. In further subgroup analyses, we found that youth with BD with comorbid attention-deficit hyperactivity disorder (ADHD) or with psychotic symptoms had more significant deficits in subcortical gray matter volume. Limitations: We cannot provide information about the course of structural changes and impact of treatment and illness progression. Conclusions: Our findings indicate that youth with BD have significant neurostructural deficits in both cortical and subcortical regions mainly located in the regions related to emotion processing and regulation. Variability in clinical characteristics and comorbidities may contribute to the severity of anatomic alterations in this disorder."

基金机构："National Institute of Mental Health (NIMH) Grant [5R01MH080973]; National Natural Science Foundation of China [81621003, 81820108018]; Innovative University Research Team (PCSIRT) [IRT16R52]; Functional and Molecular Imaging Key Laboratory of Sichuan Province (FMIKLSP) [2019JDS0044]; Chongqing Talents Exceptional Young Talents Project"

基金资助正文："This study was supported by National Institute of Mental Health (NIMH) Grant (Grant No. 5R01MH080973, DelBello) , National Natural Science Foundation of China (Grant No. 81621003, 81820108018, QYG and JAS) , Innovative University Research Team (PCSIRT, Grant No. IRT16R52 in China, QYG) , the Functional and Molecular Imaging Key Laboratory of Sichuan Province (FMIKLSP, Grant: 2019JDS0044, QYG) , and Chongqing Talents Exceptional Young Talents Project (DL) ."