"Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk"

作者全名："Qin, Kevin; Yu, Michael; Fan, Jiaming; Wang, Hongwei; Zhao, Piao; Zhao, Guozhi; Zeng, Wei; Chen, Connie; Wang, Yonghui; Wang, Annie; Schwartz, Zander; Hong, Jeffrey; Song, Lily; Wagstaff, William; Haydon, Rex C.; Luu, Hue H.; Ho, Sherwin H.; Strelzow, Jason; Reid, Russell R.; He, Tong-Chuan; Shi, Lewis L."

作者地址："[Qin, Kevin; Yu, Michael] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, N Chicago, IL 60064 USA; [Qin, Kevin; Yu, Michael; Fan, Jiaming; Wang, Hongwei; Zhao, Piao; Zhao, Guozhi; Zeng, Wei; Chen, Connie; Wang, Yonghui; Wang, Annie; Schwartz, Zander; Hong, Jeffrey; Song, Lily; Wagstaff, William; Haydon, Rex C.; Luu, Hue H.; Ho, Sherwin H.; Strelzow, Jason; Reid, Russell R.; He, Tong-Chuan; Shi, Lewis L.] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA; [Fan, Jiaming] Chongqing Med Univ, Coll Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing 400016, Peoples R China; [Fan, Jiaming] Chongqing Med Univ, Sch Lab Med, Dept Clin Biochem, Chongqing 400016, Peoples R China; [Zhao, Piao; Zhao, Guozhi] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Chongqing 400016, Peoples R China; [Zhao, Piao; Zhao, Guozhi] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China; [Zeng, Wei] Guangdong Med Univ, Dongguan Affiliated Hosp 1, Dept Intervent Neurol, Dongguan 523475, Guangdong, Peoples R China; [Wang, Yonghui] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Lab Med, Med Sch, Shanghai, Peoples R China; [Schwartz, Zander] Vanderbilt Univ, Sch Biomed Engn, Nashville, TN 37235 USA; [Wang, Annie; Reid, Russell R.; He, Tong-Chuan] Univ Chicago, Dept Surg, Lab Craniofacial Suture Biol & Dev, Med Ctr,Sect Plast Surg, Chicago, IL 60637 USA; [He, Tong-Chuan; Shi, Lewis L.] Univ Chicago, Med Ctr, Mol Oncol Lab, 5841 South Maryland Ave,MC3079, Chicago, IL 60637 USA"

通信作者："He, TC (通讯作者)，Univ Chicago, Dept Surg, Lab Craniofacial Suture Biol & Dev, Med Ctr,Sect Plast Surg, Chicago, IL 60637 USA.; He, TC; Shi, LL (通讯作者)，Univ Chicago, Med Ctr, Mol Oncol Lab, 5841 South Maryland Ave,MC3079, Chicago, IL 60637 USA."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001053240900001

JCR分区：Q1

影响因子：6.8

年份：2024

卷号：11

期号：1

开始页：103

结束页：134

文献类型：Review

关键词：beta-catenin; Canonical Wnt; Noncanonical Wnt; Signal transduction; Signaling crosstalk

摘要："Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through beta-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca2+ pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling. (c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构：Mabel Green Myers Research Endowment Fund; University of Chicago Orthopaedics Alumni Fund

基金资助正文："The reported work was supported in part by research grants from the National Institutes of Health (No. CA226303 to TCH and No. DE030480 to RRR) and the American Shoulder and Elbow Surgeons PJI Research Grant (LLS). JF was supported in part by research grants from the Natural Science Foundation of China (No. 82102696), the 2019 Science and Technology Research Plan Project of Chongqing Education Commission (China) (No. KJQN201900410), and the 2019 Funding for Postdoctoral Research (Chongqing Human Resources and Social Security Bureau No. 298). WW was supported by the Medical Scientist Training Program of the National Institutes of Health (No. T32 GM007281). This project was also supported in part by The University of Chicago Cancer Center Support Grant (No. P30CA014599) and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health through Grant Number 5UL1TR002389. TCH was also supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund. Funding sources were not involved in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication.r supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund. Funding sources were not involved in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication."