Influence of metabolic syndrome on survival of patients with localized renal clear cell carcinoma: A retrospective cohort study in China

作者全名："Liang, Ying; Zhang, Chengguo; Luo, Jun; He, Yunfeng; Zhang, Yao; Quan, Zhen; Yang, Lin"

作者地址："[Liang, Ying; Zhang, Chengguo; Luo, Jun; Yang, Lin] Chongqing Med Univ, Bishan Hosp, Dept Urol, Chongqing, Peoples R China; [He, Yunfeng; Zhang, Yao; Quan, Zhen] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China"

通信作者："Yang, L (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Urol, Chongqing, Peoples R China."

来源：UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001053382100001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：41

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：Metabolic syndrome; Localized renal clear cell carcinoma; Survival analysis; Prognosis

摘要："Objective: To assess the effects of metabolic syndrome (MetS) and its components on the survival and prognosis of patients with local-ized clear cell renal cell carcinoma (ccRCC).Design and methods: This retrospective cohort study in Chongqing, China, identified patients with localized ccRCC from two medical centers of Chongqing Medical University between January 1, 2011, and December 31, 2020. The Chinese Medical Association Diabetes Society criteria of 2004 were used to diagnose MetS. Univariate and multivariate Cox proportional hazards regression analyses were con-ducted to identify independent risk factors for ccRCC. The outcomes were overall survival (OS), progression-free survival (PFS), and can-cer-specific survival (CSS).Results: In our cohort, 378 eligible patients with localized ccRCC were included (median age, 56; range, 30-85; 255 men [67.5%]), and 87 patients (23.0%) were diagnosed with MetS. The median follow-up time was 66 months (1-126 months). Kaplan-Meier and log-rank analyses showed shorter PFS (P = 0.043) and CSS (P = 0.009) in patients with MetS. Univariate and multivariate Cox regression analyses found that MetS and dyslipidemia were independent risk factors for CSS in patients with localized ccRCC (P = 0.047; P = 0.035). When we analyzed MetS separately, the 4 components of MetS (hypertension, hyperglycemia, overweight/obesity, and dyslipidemia) did not show significant differences in OS, PFS, and CSS.Conclusion: MetS and dyslipidemia are independent adverse prognostic factors for CSS in patients with localized ccRCC. It is sug-gested to assign comprehensive therapy and follow-up to this patient population. & COPY; 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)"

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