A novel pillar[5]arene-based supramolecular fluorescent biomaterial for targeted accumulation and imaging of kidney

作者全名："Yang, Xia; Xiao, Han; He, Jiao; Yang, Li; Tao, Zhu; Xiao, Xin; Li, Qiu; Yang, Hai-ping"

作者地址："[Yang, Xia; Xiao, Han; Yang, Li; Li, Qiu; Yang, Hai-ping] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Nephrol, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China; [He, Jiao; Tao, Zhu; Xiao, Xin] Guizhou Univ, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China"

通信作者："Li, Q; Yang, HP (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Nephrol, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China.; Xiao, X (通讯作者)，Guizhou Univ, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China."

来源：SENSORS AND ACTUATORS B-CHEMICAL

ESI学科分类：CHEMISTRY

WOS号：WOS:001053560800001

JCR分区：Q1

影响因子：8.4

年份：2023

卷号：392

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Pillar[ n ]arene; Kidney; Targeted imaging; Biomaterial

摘要："Imaging the kidney is necessary to evaluate its function and track the progression of renal diseases, but it remains difficult due to invasive damage, radiation, high cost, etc. Fluorescence imaging (FLI) has received increasing attention due to its benefits, and Pillar[n]arene has attracted widespread interest due to its rigid structure, facile synthesis, and ease of functionalisation, demonstrating great imaging potential. Therefore, a novel type of functionalised Pillar[5]arene (P5DMP) with 10 positive charges was designed and created. P5DMP is a potential fluorescent material due to its major advantages, including stability, water solubility, strong biocompatibility, and superior fluorescence qualities. Notably, the positive charge design of P5DMP allows it to collect in the negatively charged filtration barrier to achieve focused accumulation and imaging of the kidney. In fact, the in vivo experiments indicated that P5DMP accumulated preferentially in the kidney with the greatest distribution in the glomeruli. The findings of the present study indicated that P5DMP may achieve a targeted and precise image of the kidney and may provide a simple and universal method for the fabrication of an outstanding renal imaging agent with significant clinical application potential."

基金机构：National Key Ramp;D Program of China [81970618]; National Natural Science Foundation of China (NSFC) [W0098]; Program for Youth Innovation in Future Medicine; Chongqing Medical University [YBRP-202126]; Basic Research Youth Project of Ministry of Education Key Laboratory of Child Development and Disorders; [2022YFC2705101]

基金资助正文："We thank the National Key R & amp;D Program of China (no. 2022YFC2705101) , National Natural Science Foundation of China (NSFC no. 81970618) , Program for Youth Innovation in Future Medicine, and Chongqing Medical University (no. W0098) , Basic Research Youth Project of Ministry of Education Key Laboratory of Child Development and Disorders (no. YBRP-202126) for financial support."