Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions

作者全名："Hong, Yifan; Wu, Shengde; Wei, Guanghui"

作者地址："[Hong, Yifan; Wu, Shengde; Wei, Guanghui] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Dept Urol,Chongqing Key Lab Children U, Chongqing 400014, Peoples R China; [Hong, Yifan] Chongqing Med Univ, Pediat Res Inst, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Wu, SD (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Dept Urol,Chongqing Key Lab Children U, Chongqing 400014, Peoples R China."

来源：SCIENCE OF THE TOTAL ENVIRONMENT

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001066507200001

JCR分区：Q1

影响因子：9.8

年份：2023

卷号：903

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Microplastics; Nanoplastics; Reproductive toxicology; Testis; Ovary

摘要："In recent years, microplastics (MPs) and nanoplastics (NPs) have caused ubiquitous environmental pollution and raised widespread concern about their potential toxicity to human health, especially in the reproductive system. Moreover, infertility affects >15 % of couples worldwide, and the birth rate is decreasing. Environmental factors are some of the most important causes of infertility. However, little is known about the effects of MPs and NPs on the testes and ovaries. These particles can enter the body primarily via ingestion, inhalation, and skin contact, target the reproductive system in a size-dependent manner and disturb germ cell and other somatic cell devel-opment. Our study systematically reviewed the adverse effects of plastic particles on reproductive function and offers valuable insights into the different stages of germ cells and the potential mechanisms. Moreover, the synergistic reproductive toxicity of these particles and carried contaminants was summarized. Given the limited research scale, a shift toward innovative technologies and the adoption of multiple omics are recommended for advancing related studies. Further study is needed to explore the reproductive toxicity of MPs and NPs based on their size, polymer type, shape, and carried toxins, establish effective protective measures, and develop precision medicine for targeted reproductive damage."

基金机构："National Natural Science Foundation of China [81771566, 82071632]; Postgraduate Research Innovation Project of Chongqing Medical University [CYB22210]; Ministry of Education of China Key Laboratory of Child Development and Disorders [YBRP-202114]"

基金资助正文："This study was supported by the National Natural Science Foundation of China (grant numbers 81771566, 82071632), the Postgraduate Research Innovation Project of Chongqing Medical University (grant number CYB22210), and the Youth Basic Research Project from the Ministry of Education of China Key Laboratory of Child Development and Disorders (No. YBRP-202114).; Our graphical abstract and schematic diagrams were created using the BioRender website (app.biorender.com). We thank AJE (www.aje. cn) for the language editing services provided.; The authors sincerely acknowledge the anonymous reviewers for their insights and comments, which helped improve the quality of the manuscript."