Aggregation-induced enhancement of pyrene-based metal-organic framework as a new electrochemiluminescence emitter for ultrasensitive detection of sulfadimethoxine

作者全名："Liu, Junjie; Mu, Zhaode; Zhou, Jing; Qing, Min; Bai, Lijuan"

作者地址："[Liu, Junjie; Zhou, Jing; Bai, Lijuan] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China; [Mu, Zhaode; Qing, Min] Chongqing Med Univ, Coll Pharm, Res Ctr Pharmacodynam Evaluat Engn Technol Chongqi, Chongqing 400016, Peoples R China"

通信作者："Bai, LJ (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China.; Qing, M (通讯作者)，Chongqing Med Univ, Coll Pharm, Res Ctr Pharmacodynam Evaluat Engn Technol Chongqi, Chongqing 400016, Peoples R China."

来源：FOOD CHEMISTRY

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001071572100001

JCR分区：Q1

影响因子：8.8

年份：2024

卷号：432

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Aggregation-induced enhancement of emission; Competitive aptasensor; Electrochemiluminescence; Pyrene-based metal-organic framework; Sulfadimethoxine

摘要："In this study, a signal-on electrochemiluminescence (ECL) aptasensor for ultrasensitive detection of sulfadimethoxine (SDM) was constructed based on a competitive aptamer strategy. Specifically, cerium-metal-organic framework (Ce-MOF) with large specific surface area and excellent electrical conductivity was combined with gold nanoparticles (AuNPs) to form a substrate, followed by the immobilisation of double-stranded DNA (dsDNA) via Au-N bonds. In the presence of SDM, the aptamer tended to form an aptamer-SDM complex, which caused dsDNA to dissociate. After release of the aptamer, the capture probe (CP) combined with the tracer label to enhance the ECL signal. As expected, the prepared sensor displayed an ideal linear response range from 10.0 fg mL-1 to 100 ng mL-1 with a limit of detection (LOD) of 1.28 fg mL-1 and successfully detected SDM in milk and quality control samples."

基金机构："Innovation in Future Medicine, Chongqing Medical University, China [W0067]; Discipline Talent Training Program of College of Phar-macy in Chongqing Medical University, China [YXY2019XSGG4, YXY2021BSH04]"

基金资助正文："This work is supported by National Natural Science Foundation of China (82072378, 81601856) , Chongqing Talents: Exceptional Young Talents Project, China (CQYC202005015, cstc2021ycjh-bgzxm0328) , Ba Yu Scholar Program, China (YS2019020) , Natural Science Foundation of Chongqing, China (CSTB2022NSCQ-BHX0006) , Special Funding for Postdoctoral Research Project of Chongqing, China (2021XM2045) , Funds for High Level Young Science and Technology Talent Cultivation Plan in Chongqing Medical University, China (2019) , Program for YouthInnovation in Future Medicine, Chongqing Medical University, China (W0067) and Discipline Talent Training Program of College of Pharmacy in Chongqing Medical University, China (YXY2019XSGG4, YXY2021BSH04) .r Innovation in Future Medicine, Chongqing Medical University, China (W0067) and Discipline Talent Training Program of College of Phar-macy in Chongqing Medical University, China (YXY2019XSGG4, YXY2021BSH04) ."