"Association of diabetes risk reduction diet with renal cancer risk in 101,755 participants: a prospective study"

作者全名："Xiang, Ling; Xiao, Yi; Xu, Zhiquan; Luo, Haoyun; Ren, Xiaorui; Wei, Qi; Zhu, Zhiyong; Jiang, Yahui; Tang, Yunhao; He, Hongmei; Zhou, Zhihang; Gu, Haitao; Wang, Yaxu; Peng, Linglong"

作者地址："[Xiang, Ling] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Chongqing, Peoples R China; [Xiao, Yi; Xu, Zhiquan; Luo, Haoyun; Ren, Xiaorui; Wei, Qi; Zhu, Zhiyong; Jiang, Yahui; Tang, Yunhao; He, Hongmei; Gu, Haitao; Wang, Yaxu; Peng, Linglong] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, 288 Tianwen Ave, Chongqing 400010, Peoples R China; [Zhou, Zhihang] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Xiao, Y; Wang, YX; Peng, LL (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, 288 Tianwen Ave, Chongqing 400010, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001079534600002

JCR分区：Q1

影响因子：7.4

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Diabetes risk reduction diet; Renal cancer; Cancer prevention; Epidemiology; Dietary pattern

摘要："Background There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence to DRRD was associated with a reduced risk of renal cancer in a US population.Methods A population-based cohort of 101,755 American adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. A DRRD score was calculated to assess adherence to this dietary pattern, where increased scores indicated greater adherence. The relationship between DRRD score and risk of renal cancer was assessed based on the hazard ratios (HRs) and 95% confidence intervals (CIs), which were both calculated using Cox regression. Non-linear association was determined through restricted cubic spline regression. Potential effect modifiers were identified through subgroup analyses.Results Over a mean follow-up of 8.8 years, 446 renal cancers were detected. In this analysis, the fully adjusted model depicted a notable 29% reduction in the risk of renal cancer among individuals in the highest quartile of DRRD score in comparison with the lowest quartile individuals (HRQ4 vs. Q1: 0.71; 95% CI = 0.54, 0.94; P-trend = 0.008). This association remained consistent across a series of sensitivity analyses. A non-linear inverse dose-response association between renal cancer risk with DRRD score was observed (P-nonlinearity = 0.026). Subgroup analyses showed that this favorable link was more prominent in participants with low Healthy Eating Index-2015 (P-interaction = 0.015). Regarding the individual components of DRRD, a decrease in the risk of renal cancer was linked to increased intake of cereal fiber and whole fruit, and lower sugar-sweetened beverage consumption (all P-trend < 0.05).Conclusions Our findings indicate that individuals adhering to DRRD are associated with a reduction in the risk of renal cancer."

基金机构："General Project of Chongqing Natural Science Foundation; Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153, cstc2021jcyj-msxmX0112, CSTB2022NSCQ-MSX1005]; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110]"

基金资助正文："This work was supported by The General Project of Chongqing Natural Science Foundation, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153 (Linglong Peng)], [cstc2021jcyj-msxmX0112 (Yaxu Wang)], and [CSTB2022NSCQ-MSX1005 (Haitao Gu)], and Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110 (Haitao Gu)]."