Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects

作者全名："Li, Xiandeng; Zhang, Ying; Xing, Xiaodong; Li, Mi; Liu, Yan; Xu, Ajing; Zhang, Jian"

作者地址："[Li, Xiandeng; Zhang, Ying; Xing, Xiaodong; Li, Mi; Liu, Yan; Xu, Ajing; Zhang, Jian] Shanghai Jiao Tong Univ, Dept Clin Pharm, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China; [Li, Xiandeng; Xing, Xiaodong] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Xu, AJ; Zhang, J (通讯作者)，Shanghai Jiao Tong Univ, Dept Clin Pharm, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001092391900001

JCR分区：Q1

影响因子：7.5

年份：2023

卷号：168

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Podocyte injury; Diabetic nephropathy; Pharmacotherapy; Proteinuria

摘要："Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it has emerged as a major contributor to endstage renal disease. The glomerular filtration barrier, composed of podocytes, endothelial cells, and the glomerular basement membrane, plays a vital role in maintaining renal function. Disruptions in podocyte function, including hypertrophy, shedding, reduced density, and apoptosis, can impair the integrity of the glomerular filtration barrier, resulting in elevated proteinuria, abnormal glomerular filtration rate, and increased creatinine levels. Hence, recent research has increasingly focused on the role of podocyte injury in DN, with a growing emphasis on exploring therapeutic interventions targeting podocyte injury. Studies have revealed that factors such as lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, and impaired autophagy can contribute to podocyte injury. This review aims to summarize the underlying mechanisms of podocyte injury in DN and provide an overview of the current research status regarding experimental drugs targeting podocyte injury in DN. The findings presented herein may offer potential therapeutic targets and strategies for the management of DN associated with podocyte injury."

基金机构：National Key Research and Develop- ment Program of China [2020YFC2005502]; Science and Tech- nology Commission of Shanghai Municipality [19401900500]

基金资助正文：<BOLD>Funding</BOLD> This work was funded by the National Key Research and Develop- ment Program of China (2020YFC2005502) and the Science and Tech- nology Commission of Shanghai Municipality (Project No. 19401900500) .