Multimodal Investigation of Deep Gray Matter Nucleus in Patients with Multiple Sclerosis and Their Clinical Correlations: A Multivariate Pattern Analysis Study

作者全名："Yin, Feiyue; Yan, Zichun; Li, Yongmei; Ding, Shuang; Wang, Xiaohua; Shi, Zhuowei; Feng, Jinzhou; Du, Silin; Tan, Zeyun; Zeng, Chun"

作者地址："[Yin, Feiyue; Yan, Zichun; Li, Yongmei; Wang, Xiaohua; Shi, Zhuowei; Du, Silin; Tan, Zeyun; Zeng, Chun] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Ding, Shuang] Chongqing Med Univ, Childrens'Hospital, Dept Radiol, Chongqing 400015, Peoples R China; [Feng, Jinzhou] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China"

通信作者："Zeng, C (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China."

来源：JOURNAL OF PERSONALIZED MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001093603200001

JCR分区：　

影响因子：　

年份：2023

卷号：13

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：magnetic resonance imaging; multiple sclerosis; deep gray matter; diffusion tensor imaging

摘要："Deep gray matter (DGM) nucleus are involved in patients with multiple sclerosis (MS) and are strongly associated with clinical symptoms. We used machine learning approach to further explore microstructural alterations in DGM of MS patients. One hundred and fifteen MS patients and seventy-one healthy controls (HC) underwent brain MRI. The fractional anisotropy (FA), mean diffusivity (MD), quantitative susceptibility value (QSV) and volumes of the caudate nucleus (CN), putamen (PT), globus pallidus (GP), and thalamus (TH) were measured. Multivariate pattern analysis, based on a machine-learning algorithm, was applied to investigate the most damaged regions. Partial correlation analysis was used to investigate the correlation between MRI quantitative metrics and clinical neurological scores. The area under the curve of FA-based classification model was 0.83, while they were 0.93 for MD and 0.81 for QSV. The Montreal cognitive assessment scores were correlated with the volume of the DGM and the expanded disability status scale scores were correlated with the MD of the GP and PT. The study results indicated that MS patients had involvement of DGM with the CN being the most affected. The atrophy of DGM in MS patients mainly affected cognitive function and the microstructural damage of DGM was mainly correlated with clinical disability."

基金机构：The authors thank the study participants for their contributions to the study.

基金资助正文：The authors thank the study participants for their contributions to the study.