Add-Back and Combined Regulation in GnRH-a Treatment of Endometriosis

作者全名："Tang, Huimin; Jia, Qiucheng; Dong, Zhiyong; Chen, Yao; Shan, Wulin; Wu, Yihan; Miao, Miao; Xing, Tingwei; Wei, Weiwei; Tang, Bin; Zheng, Hong; Shi, Ruxia; Xia, Bairong; Chen, Jiming"

作者地址："[Tang, Huimin; Jia, Qiucheng; Wu, Yihan; Miao, Miao; Xing, Tingwei; Wei, Weiwei; Tang, Bin; Zheng, Hong; Shi, Ruxia; Chen, Jiming] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Gynecol, Changzhou 213000, Jiangsu, Peoples R China; [Dong, Zhiyong] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing 400010, Peoples R China; [Chen, Yao; Shan, Wulin; Xia, Bairong] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Gynecol, Div Life Sci & Med, Hefei 230031, Anhui, Peoples R China"

通信作者："Chen, JM (通讯作者)，Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Gynecol, Changzhou 213000, Jiangsu, Peoples R China.; Xia, BR (通讯作者)，Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Gynecol, Div Life Sci & Med, Hefei 230031, Anhui, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001101090700011

JCR分区：Q4

影响因子：0.2

年份：2023

卷号：50

期号：10

开始页：　

结束页：　

文献类型：Review

关键词：add-back therapy; combined regulation; endometriosis; GnRH-a; sex hormone

摘要："Objective: The purpose of this review is to summarize drug selection for peri-menopausal symptoms caused by gonadotropin releasing-hormone agonist (GnRH-a) in the treatment of endometriosis. Mechanism: GnRH-a treatment often leads to low estrogen levels, resulting in peri-menopausal symptoms and osteoporosis. Add-back therapy relieves clinical symptoms by supplementing low-dose estrogen. The idea of ""combined regulation"" is to improve symptoms by adding plant preparations or proprietary Chinese medicines. Studies have shown that they may play a role by regulating serotonin activity. Findings in Brief: For patients treated with GnRH-a for less than 3 months, the combined-regulation regimen can be considered, whereas for patients who have had more than 3 courses of GnRH-a, add-back therapy with sex hormones must be used because the patients will have begun to have obvious bone-mass loss and even bone pain; this bone-mass loss is often irreversible. Conclusions: In the early treatment of endometriosis with GnRH-a, non-hormone combined-regulation therapy is a relatively safe and feasible choice, but hormone add-back therapy should be selected for patients who have had more than 3 courses of GnRH-a."

基金机构：nal and child health key talent project of Jiangsu Province [RC202101]; maternal and child health research project of Jiangsu Province [F202138]; Scientific Research Support Program for Postdoctoral of Jiangsu Province [2019K064]; Scientific Research Support Program for "333 Project" of Jiangsu Province [BRA2019161]

基金资助正文："This work was supported by grants from Top Talent of Changzhou ""The 14th Five-Year Plan"" High-Level Health Talents Training Project (2022CZBJ074), the maternal and child health key talent project of Jiangsu Province (RC202101), the maternal and child health research project of Jiangsu Province (F202138), the Scientific Research Support Program for Postdoctoral of Jiangsu Province (2019K064), and the Scientific Research Support Program for ""333 Project"" of Jiangsu Province (BRA2019161).r nal and child health key talent project of Jiangsu Province (RC202101) , the maternal and child health research project of Jiangsu Province (F202138) , the Scientific Research Support Program for Postdoctoral of Jiangsu Province (2019K064) , and the Scientific Research Support Program for ""333 Project"" of Jiangsu Province (BRA2019161) ."