Virtual reality working memory training improves cognitive performance of acute and remitted patients with major depressive disorder

作者全名："Yan, Shuya; Shen, Shiyi; Lu, Qianyi; Zhong, Shuming; Lv, Sihui; Lai, Shunkai; Luo, Yange; Ran, Hanglin; Duan, Manying; Song, Kailin; Ye, Kaiwei; Jia, Yanbin"

作者地址："[Yan, Shuya; Shen, Shiyi; Lu, Qianyi; Zhong, Shuming; Lv, Sihui; Lai, Shunkai; Jia, Yanbin] Jinan Univ, Dept Psychiat, Affiliated Hosp 1, Guangzhou 510630, Peoples R China; [Shen, Shiyi; Luo, Yange; Ran, Hanglin; Duan, Manying; Song, Kailin; Ye, Kaiwei] Jinan Univ, Sch Management, Guangzhou 510630, Peoples R China; [Lu, Qianyi] Guangdong Univ Finance, Guangzhou 510521, Peoples R China; [Luo, Yange] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Clin Psychol, Shenzhen 518033, Peoples R China; [Ran, Hanglin] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China"

通信作者："Jia, YB (通讯作者)，Jinan Univ, Dept Psychiat, Affiliated Hosp 1, Guangzhou 510630, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001101759700001

JCR分区：Q1

影响因子：6.6

年份：2024

卷号：344

期号：　

开始页：267

结束页：276

文献类型：Article

关键词：Working memory training; Major depressive disorder; Immersive virtual reality

摘要："Background: Cognitive training is effective in treating neuropsychological impairment in patients with major depressive disorder (MDD), and virtual reality (VR) is a promising tool to provide such training. However, studies using VR-based working memory (WM) training in treating depressed patients' cognitive impairment are extremely scarce and how it affects cognitive performance remains unclear. Therefore, we aimed to determine the efficacy of VR-WM training in acute and remitted depressed patients and try to investigate its potential mechanisms. Methods: Forty-two patients with MDD (22 acute patients and 20 remitted patients) received 20-session VR-WM training, while 22 healthy controls (HC) received no intervention. WM and other cognitive domains' performance were assessed by the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (CPFQ) and the MATRICS Consensus Cognitive Battery (MCCB) before and after the intervention. Depressive symptoms were assessed by the 24-item Hamilton Depression Rating Scale (24-HDRS) at the same time points.Results: Acute and remitted MDD patients both exhibited significant improvements from pre-to post-training in WM, processing speed, visual learning, reasoning and problem-solving, and total cognition (all p < 0.05). Sig-nificant groups-by-time interactions were observed for the 24-HDRS score (p < 0.05). Mediation analysis showed that 24-HDRS score partially mediated the association between the effect of VR-WM training on WM and total cognition performance in total depressive samples.Conclusions: VR-WM training effectively improved WM and other cognitive domains' performance in both acute and remitted MDD patients. Besides, VR-WM training improves WM and total cognition performance in MDD patients partially via the enhancement of depressive symptoms."

基金机构："National Natural Science Foundation of China [82271564]; Science and Technology Planning Project of Guangzhou, China [202201010568]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (General Program) (grant number 82271564); and the Science and Technology Planning Project of Guangzhou, China (grant number 202201010568). The funders have not played any roles in study design, data collection, analysis, manuscript writing and decision to publish."