TCF4 and RBFOX1 as peripheral biomarkers for the differential diagnosis and treatment of major depressive disorder

作者全名："Xu, Ke; Ren, Yi; Fan, Li; Zhao, Shuang; Feng, Jinzhou; Zhong, Qi; Tu, Dianji; Wu, Wentao; Chen, Jianjun; Xie, Peng"

作者地址："[Xu, Ke; Ren, Yi; Fan, Li; Feng, Jinzhou; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Xu, Ke; Ren, Yi; Fan, Li; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Chongqing 400016, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Minist Educ,Key Lab Mol Biol Infec, Chongqing 400010, Peoples R China; [Zhao, Shuang] Dept Histol & Embryol, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China; [Zhong, Qi; Wu, Wentao; Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Tu, Dianji] Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Clin Lab, Chongqing 400037, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.; Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001102283800001

JCR分区：Q1

影响因子：6.6

年份：2024

卷号：345

期号：　

开始页：252

结束页：261

文献类型：Article

关键词：Major depressive disorder; Transcription factor 4; RBFOX1; Biomarkers

摘要："Background: Recent genome-wide association studies on major depressive disorder (MDD) have indicated the involvement of LRFN5 and OLFM4; however, the expression levels and roles of these molecules in MDD remain unclear. The present study aimed to determine the serum levels of TCF4 and RBFOX1 in patients with MDD and to investigate whether these molecules could be used as biomarkers for MDD diagnosis.Methods: The study included 99 drug-naive MDD patients, 90 drug-treated MDD patients, and 81 healthy controls (HCs). Serum TCF4 and RBFOX1 levels were measured by ELISA. Pearson's correlation analysis was conducted to determine the association between TCF4/RBFOX1 and clinical variables. Linear support vector machine classifier was used to evaluate the diagnostic capabilities of TCF4 and RBFOX1.Results: Serum TCF4 and RBFOX1 levels were substantially higher in MDD patients than in HCs and significantly lower in drug-treated MDD patients than in drug-naive MDD patients. Moreover, serum TCF4 and RBFOX1 levels were associated with the Hamilton Depression Scale score, duration of illness, serum lipids levels, and hepatic function. Thus, both these molecules showed potential as biomarkers for MDD. TCF4 and RBFOX1 combination exhibited a higher diagnostic performance, with the mean area under the curve values of 0.9861 and 0.9936 in the training and testing sets, respectively.Limitations: Small sample size and investigation of only the peripheral nervous system.Conclusions: TCF4 and RBFOX1 may be involved in the pathogenesis of MDD, and their combination may serve as a diagnostic biomarker panel for MDD."

基金机构："National Key R&D Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; National Natural Science Foundation of China [81820108015, 82301720]; China Postdoctoral Science Foundation [2023MD734128]; Chongqing Post-doctoral Science Foundation [CSTB2023NSCQ-BHX0214]; First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation [CYYY-BSHPYXM-202310]"

基金资助正文："This work was supported by the National Key R & D Program of China (2017YFA0505700); Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002); National Natural Science Foundation of China (81820108015, 82301720); China Postdoctoral Science Foundation (2023MD734128); Chongqing Post-doctoral Science Foundation (CSTB2023NSCQ-BHX0214); The First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310)."