The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors
作者全名："Zhang, Bo; Zhang, Hao; Wang, Zeyu; Cao, Hui; Zhang, Nan; Dai, Ziyu; Liang, Xisong; Peng, Yun; Wen, Jie; Zhang, Xun; Zhang, Liyang; Luo, Peng; Zhang, Jian; Liu, Zaoqu; Cheng, Quan; Peng, Renjun"
作者地址："[Zhang, Bo; Zhang, Hao; Wang, Zeyu; Dai, Ziyu; Liang, Xisong; Wen, Jie; Zhang, Xun; Zhang, Liyang; Cheng, Quan; Peng, Renjun] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China; [Zhang, Bo; Dai, Ziyu; Liang, Xisong; Wen, Jie; Zhang, Xun; Zhang, Liyang; Cheng, Quan; Peng, Renjun] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China; [Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Wang, Zeyu] Univ Edinburgh, Inst Regenerat & Repair, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Scotland; [Cao, Hui] Hunan Univ Chinese Med, Sch Clin Med, Dept Psychiat, Changsha, Peoples R China; [Zhang, Nan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Peoples R China; [Peng, Yun] Cent South Univ, Xiangya Hosp, Teaching & Res Sect Clin Nursing, Changsha, Peoples R China; [Peng, Yun] Cent South Univ, Xiangya Hosp, Dept Geriatr, Changsha, Peoples R China; [Luo, Peng; Zhang, Jian] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China; [Liu, Zaoqu] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Cheng, Quan; Peng, Renjun] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China"
通信作者："Cheng, Q; Peng, RJ (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China."
来源：CNS NEUROSCIENCE & THERAPEUTICS
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
WOS号：WOS:001103974400001
JCR分区：Q1
影响因子：5.5
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Review; Early Access
关键词：circRNA; CNS tumors; chemotherapy; immunotherapy; radiotherapy
摘要："Background: Central nervous system (CNS) tumors originate from the spinal cord or brain. The study showed that even with aggressive treatment, malignant CNS tumors have high mortality rates. However, CNS tumor risk factors and molecular mechanisms have not been verified. Due to the reasons mentioned above, diagnosis and treatment of CNS tumors in clinical practice are currently fraught with difficulties. Circular RNAs (circRNAs), single-stranded ncRNAs with covalently closed continuous structures, are essential to CNS tumor development. Growing evidence has proved the numeral critical biological functions of circRNAs for disease progression: sponging to miRNAs, regulating gene transcription and splicing, interacting with proteins, encoding proteins/peptides, and expressing in exosomes.Aims: This review aims to summarize current progress regarding the molecular mechanism of circRNA in CNS tumors and to explore the possibilities of clinical application based on circRNA in CNS tumors.Methods: We have summarized studies of circRNA in CNS tumors in Pubmed.Results: This review summarized their connection with CNS tumors and their functions, biogenesis, and biological properties. Furthermore, we introduced current advances in clinical RNA-related technologies. Then we discussed the diagnostic and therapeutic potential (especially for immunotherapy, chemotherapy, and radiotherapy) of circRNA in CNS tumors in the context of the recent advanced research and application of RNA in clinics.Conclusions: CircRNA are increasingly proven to participate in decveloping CNS tumors. An in-depth study of the causal mechanisms of circRNAs in CNS tomor progression will ultimately advance their implementation in the clinic and developing new strategies for preventing and treating CNS tumors."
基金机构："National Natural Science Foundation of China [82073893, 81703622, 81901268]; Natural Science Foundation of Hunan Province [2022JJ20095]; Hunan Provincial Health Committee Foundation of China [202204044869]"
基金资助正文："National Natural Science Foundation of China, Grant/Award Number: 82073893, 81703622 and 81901268; Natural Science Foundation of Hunan Province, Grant/Award Number: 2022JJ20095; Hunan Provincial Health Committee Foundation of China, Grant/Award Number: 202204044869"
