Nucleated red blood cells as a novel biomarker in the diagnosis and prediction of sepsis severity in children

作者全名："Li, Hongdong; Tu, Qianqian; Feng, Kun; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping"

作者地址："[Li, Hongdong; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping] Chongqing Med Univ, Dept Emergency, Childrens Hosp, Chongqing, Peoples R China; [Li, Hongdong; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Li, Hongdong; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Li, Hongdong; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping] China Int Sci & Technol, Cooperat Base Child Dev & Crit Disorders, Chongqing, Peoples R China; [Li, Hongdong; Cheng, Jie; Zou, Zhiping; Li, Shaojun; Tan, Liping] Chongqing Key Lab Child Infect & Immun, Chongqing, Peoples R China; [Tu, Qianqian] Chongqing Med Univ, Dept Clin Lab, Childrens Hosp, Chongqing, Peoples R China; [Feng, Kun] Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Tan, LP (通讯作者)，Chongqing Med Univ, Dept Emergency, Childrens Hosp, Chongqing, Peoples R China.; Tan, LP (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Tan, LP (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Tan, LP (通讯作者)，China Int Sci & Technol, Cooperat Base Child Dev & Crit Disorders, Chongqing, Peoples R China.; Tan, LP (通讯作者)，Chongqing Key Lab Child Infect & Immun, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001104556100001

JCR分区：Q2

影响因子：5.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：nucleated red blood cell; biomarker; sepsis; prognosis; children

摘要："Introduction Sepsis is a vitally serious disease leading to high mortality. Nucleated red blood cells (NRBCs) are present in some noninfectious diseases, but the relationship between NRBCs and sepsis in children remains unknown. The purpose of this study was to compare the clinical characteristics and outcomes of sepsis with positive NRBCs and negative NRBCs in children, and to further explore whether the count of NRBCs has a relationship with the severity of sepsis.Methods We enrolled children with sepsis who were admitted to the Children's Hospital of Chongqing Medical University between January 2020 and December 2022. The children's clinical data, laboratory data and outcomes were recorded and analyzed.Results One hundred and fifteen children met the inclusion criteria in our study. Compared to negative NRBCs patients, the C-reactive protein, alanine transaminase, urea nitrogen values, mortality rate and length of hospitalization were found to be significantly increased, while platelet counts, and hemoglobin were significantly decreased in sepsis patients with positive NRBC (P < 0.05). Receiver operating characteristic (ROC) curves analysis showed that the optimal cutoff value of the NRBC count in the diagnosis of severe sepsis was 3, with a sensitivity of 87.5% and specificity of 94.9%. The area under the ROC curve was 0.877 (95% CI: 0.798-0.957).Discussion These findings demonstrated that NRBC count has the potential to be a biomarker for the diagnosis of sepsis in children, especially an NRBC count greater than 3, which may predict the severity and poor prognosis in children suffering from sepsis."

基金机构："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Chongqing Science and Technology Bureau and Health Commission Joint Medical Project (2021MSXM025), the Sci [2021MSXM025]; Chongqing Science and Technology Bureau and Health Commission Joint Medical Project; Science and Technology Research Program of Chongqing Municipal Education Commission"

基金资助正文："We are grateful to American Journal Experts for their valuable advice to the linguistic revision of the manuscript.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Chongqing Science and Technology Bureau and Health Commission Joint Medical Project (2021MSXM025), the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No.KJQN202300459)."