"Br?nsted-Acid Mediated Synthesis of Symmetrical and Unsymmetrical Indolo[2,3-a]carbazoles from Indoles and <i>α</i>-Functionalized Ketones"

作者全名："Xu, Teling; Huang, Shanshan; Tan, Linbo; Zhang, Xueyan; Jiang, Wengao; Luo, Juan; Tang, Qiang"

作者地址："[Xu, Teling; Huang, Shanshan; Zhang, Xueyan; Jiang, Wengao; Tang, Qiang] Chongqing Med Univ, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Tan, Linbo] Chongqing Med Univ, Childrens Hosp, Chongqing 400016, Peoples R China; [Luo, Juan] Chongqing Med Univ, Ctr Lab Teaching & Management, Chongqing 400016, Peoples R China"

通信作者："Tang, Q (通讯作者)，Chongqing Med Univ, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：ADVANCED SYNTHESIS & CATALYSIS

ESI学科分类：CHEMISTRY

WOS号：WOS:001104940700001

JCR分区：Q1

影响因子：5.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Indolocarbazole; Unsymmetrical synthesis; Chemoselectivity; Cascade; Bronsted-acid catalysis

摘要："Various symmetrical and unsymmetrical indolo[2,3-a]carbazoles were synthesized in a one- or two-step reaction using alpha-haloketones and indoles. The developed methodology demonstrated controllable chemoselectivity and gram-scale synthesis. Furthermore, this transformation was compatible with other alpha-functionalized ketones, such as alpha-hydroxy and alpha-acetyloxy ketones, allowing for the formation of their corresponding indolocarbazoles. Additionally, our photochemical research has revealed that all the indolo[2,3-a]carbazoles exhibited dual fluorescence, with the relative intensity varying depending on the solvent."

基金机构：We appreciate the financial support from the Natural Science Foundation of Chongqing city of China (CSTB2022NSCQ-MSX0847). [CSTB2022NSCQ-MSX0847]; Natural Science Foundation of Chongqing city of China

基金资助正文：We appreciate the financial support from the Natural Science Foundation of Chongqing city of China (CSTB2022NSCQ-MSX0847).