Patterns of <i>de novo</i> metastasis and survival outcomes by age in breast cancer patients: a SEER population-based study

作者全名："Xiao, Qian; Zhang, Weixiao; Jing, Jingfeng; Zhong, Tingting; Li, Daxue; Zhou, Jing; Liu, Pan; Duan, Zhongxu; Gao, Han; Shen, Liyuan"

作者地址："[Xiao, Qian; Jing, Jingfeng; Li, Daxue; Zhou, Jing; Duan, Zhongxu; Gao, Han] Chongqing Med Univ, Women & Childrens Hosp, Dept Breast & Thyroid Surg, Chongqing, Peoples R China; [Xiao, Qian; Jing, Jingfeng; Li, Daxue; Zhou, Jing; Duan, Zhongxu; Gao, Han] Chongqing Hlth Ctr Women & Children, Dept Breast & Thyroid Surg, Chongqing, Peoples R China; [Zhang, Weixiao] Chongqing Jiangbei Hosp Tradit Chinese Med, Dept Nutr, Chongqing, Peoples R China; [Zhong, Tingting] Chongqing Gen Hosp, Dept Cardiol, Chongqing, Peoples R China; [Liu, Pan] Third Mil Med Univ, Daping Hosp, Affiliated Hosp 3, Dept Rheumatol, Chongqing, Peoples R China; [Shen, Liyuan] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Shen, Liyuan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China"

通信作者："Gao, H (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Breast & Thyroid Surg, Chongqing, Peoples R China.; Gao, H (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Breast & Thyroid Surg, Chongqing, Peoples R China.; Shen, LY (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Shen, LY (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001105792400001

JCR分区：Q2

影响因子：5.2

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：de novo metastatic breast cancer; age; overall survival; breast cancer-specific survival; SEER

摘要："Background The role of age in metastatic disease, including breast cancer, remains obscure. This study was conducted to determine the role of age in patients with de novo metastatic breast cancer.Methods Breast cancer patients diagnosed with distant metastases between 2010 and 2019 were retrieved from the Surveillance, Epidemiology, and End Results database. Comparisons were performed between young (aged <= 40 years), middle-aged (41-60 years), older (61-80 years), and the oldest old (> 80 years) patients. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were estimated using multivariate Cox proportional hazard models. Survival analysis was performed by the Kaplan-Meier method.Results This study included 24155 (4.4% of all patients) de novo metastatic breast cancer patients. The number of young, middle-aged, older, and the oldest old patients were 195 (8.3%), 9397 (38.9%), 10224 (42.3%), and 2539 (10.5%), respectively. The 5-year OS rate was highest in the young (42.1%), followed by middle-aged (34.8%), older (28.3%), and the oldest old patients (11.8%). Multivariable Cox regression analysis showed that middle-aged (aHR, 1.18; 95% CI, 1.10-1.27), older (aHR, 1.42; 95% CI, 1.32-1.52), and the oldest old patients (aHR, 2.15; 95% CI, 1.98-2.33) had worse OS than young patients. Consistently, middle-aged (aHR, 1.16; 95% CI, 1.08-1.25), older (aHR, 1.32; 95% CI, 1.23-1.43), and the oldest old patients (aHR, 1.86; 95% CI, 1.71-2.03) had worse BCSS than young patients.Conclusion This study provided clear evidence that de novo metastatic breast cancer had an age-specific pattern. Age was an independent risk factor for mortality in patients with de novo metastatic breast cancer"

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